Impact of Transcranial Direct Current Stimulation on Language Functions in Mild Cognitive Impairment: A Proof-of-principle Study and Neural Correlates
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Mild Cognitive Impairment
- Sponsor
- Charite University, Berlin, Germany
- Enrollment
- 18
- Locations
- 1
- Primary Endpoint
- Number of correct responses during word-generation tasks (max. 60)
- Status
- Completed
- Last Updated
- 12 years ago
Overview
Brief Summary
The purpose of this study is to determine if non-invasive electrical brain stimulation can improve word-retrieval in Mild Cognitive Impairment (MCI).
Detailed Description
Previous studies showed that anodal transcranial direct current stimulation (atDCS) can have beneficial effects on word-retrieval in healthy younger and older subjects. The present study aims to extend these findings by assessing whether atDCS can also improve known impairments of word-retrieval in Mild Cognitive Impairment. atDCS will be applied to the left inferior frontal gyrus in a sham controlled cross-over within subjects design. Simultaneous functional magnetic resonance imaging (fMRI) will assess underlying neural effects of the stimulation.
Investigators
Marcus Meinzer
Creutzfeld Fellow
Charite University, Berlin, Germany
Eligibility Criteria
Inclusion Criteria
- •right handed
- •German native speakers
- •clinical diagnosis of Mild Cognitive Impairment
Exclusion Criteria
- •other current or previous neurological or current psychiatric diseases
- •alcohol or drug abuse
- •MRI contraindication (e.g., magnetic metal, pacemaker, claustrophobia
Outcomes
Primary Outcomes
Number of correct responses during word-generation tasks (max. 60)
Time Frame: Change in number of correct responses between Assessment 1 (week 1) and Assessment 2 (week 2), assessments 1 and 2 are seperated by one week
Subjects are assessed in a cross-over design. The primary outcome measure will be assessed twice in each subject, either during sham stimulation or active stimulation with transcranial direct current stimulation. Order of stimulation (sham, atDCS or atDCS, sham) will be counterbalanced across the group. The study design has been described in detail before (Meinzer et al., 2012, Journal of Neuroscience, 32:1859 -1866).
Secondary Outcomes
- Neural activity during word-generation task assessed by functional magnetic resonance imaging (fMRI)(Change in fMRI activity between Assessment 1 (week 1) and Assessment 2 (week 2), assessments 1 and 2 are seperated by one week)