Ablation of both the inside and outside of the heart versus the inside of the heart only for patients with persistent atrial fibrillatio

Not Applicable

• Conditions: Cardiovascular disease; Circulatory System

• Registration Number: ISRCTN18419796
• Lead Sponsor: niversity Hospitals Sussex NHS Foundation Trust

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2023-08-29
• Last Update Posted: 11 September 2023
• Study Completion: 2026-05-01

Recruitment & Eligibility

• Status: Ongoing
• Sex: All
• Target Recruitment: 166

Inclusion Criteria

1. Previous left atrial ablation with pulmonary vein isolation only
2. Indicated for repeat catheter ablation for documented symptomatic recurrent persistent AF
3. Aged > 18 years
4. Willing and able to provide informed consent
5. Willing and able to comply with the study requirements

Exclusion Criteria

1. Pregnancy or planning pregnancy
2. Previous cardiac surgery
3. Previous pericarditis
4. Previous linear ablation in the LA
5. LA diameter > 55 mm in TTE
6. Current involvement in another interventional clinical trial
7. Contraindication to anticoagulation
8. Longstanding persistent AF lasting more than 2 years in duration
9. Cyanotic congenital heart disease
10. Body Mass Index > 40
11. Unable to use a smartphone with the ‘myMerlin’ application
12. Failure to achieve sinus rhythm, despite a maximum of 4x cardioversions +/- IV antiarrhythmic drugs
13. Failure to achieve epicardial access, via the CO2 insufflation technique
14. Re-assessment of PVI after the 20-minute waiting period
15. Implantable cardiac monitor permanently explanted, during the blanking period

Study & Design

• Study Type: Interventional
• Study Design: Not specified