Effect of Oral Supplementation With Curcumin (Turmeric) in Patients With Proteinuric Chronic Kidney Disease
试验速览
- 阶段
- 3 期
- 状态
- 已完成
- 发起方
- 入组人数
- 120
- 试验地点
- 1
- 主要终点
- Change in proteinuria
研究概览
简要总结
The purpose of this study is to determine if the oral supplementation with curcumin reduces proteinuria in patients with chronic kidney disease regardless the ethiology.
详细描述
Curcumin is a potent antioxidant found in extracts of the rhizome of the plant Curcuma longa L.
Different studies have demonstrated that curcumin has potent biological activity and therefore is an effective therapeutic agent for the treatment of various ailments.
This compound acts as a bifunctional antioxidant:
ه is capable of reacting directly with highly reactive oxygen species. ه acts indirectly by its ability to induce the expression of various cytoprotective proteins through Keap1/Nrf2/ARE pathway.
Although RAAS blockade is the cornerstone to prevent the progression of proteinuric nephropathy, a significant number of patients remained with proteinuria and progress to end-stage renal disease.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Diagnosis of proteinuric chronic kidney disease with 1g or more of proteins in a daily recollection.
- •Individuals taking Angiotensin II Receptor Blocker or ACE inhibitors in monotherapy with maximum dose or in combination.
排除标准
- •Hepatic damage.
- •Malignancy.
- •Pregnancy.
- •Peritoneal or hemodialysis.
- •Organ transplantation.
- •Heart failure classification III or IV (New York Heart Association).
- •History of chemotherapy within 2 years prior to screening.
研究组 & 干预措施
Diabetic
干预措施: Curcumin (Drug)
Non-diabetic
干预措施: Curcumin (Drug)
结局指标
主要结局
Change in proteinuria
时间窗: 8 weeks
次要结局
未报告次要终点
研究者
Magdalena Madero
MD
Instituto Nacional de Cardiologia Ignacio Chavez