The effects of vitamin D and synbiotic co-supplementation on HbA1c, Metabolic Profile, Serum Concentration of some biomarkers of inflammation, oxidative stress and quality of life in patients with type 1 diabetes

Iran University of Medical Sciences0 个研究点目标入组 114 人开始时间: 待定最近更新: 2019年10月7日

适应症

试验速览

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•Desire to cooperate and sign a written informed consent
•HbA1c more than 7% (Based on the American Diabetes Association's Guidelines to Uncontrolled Diabetes)
•Duration of the Disease more than 1 Year
•Treatment with Multiple Injections of Insulin (Regular, NPH, Glargine, Detemir, Aspartate, Glulosin, Lispro)

•autoimmune disorders (celiac, hashimato, asthma, allergies, ..)
•Severe Hypoglycemia so that the Person Needs Another Person's Help to Resolve the Condition (3 Times or more During the Last Year, 1 or more in the Last 3 Months)
•Hyperglycemia Leads to Ketoacidosis over the Past Month
•Use of Mixed Insulin (Novomix and 70/30)
•taking vitamin D supplements (oral and Injection)
•taking synbiotic supplement
•taking calcium-vitamin D
•taking multivitamin-minerals
•taking antioxidant or anti-inflammatory such as vitamins E and C supplements, omega-3 fatty acids
•taking Consumption of Vitamin D-Enriched Foods over the Past 3 Months
•Severe Complications of Diabetes (Advanced Macrovascular and Microvascular Complications Including Major Cardiovascular Disorders (Acute Myocardial Infarction, Coronary Artery Bypass, Stroke and Peripheral Arterial Disease), Severe Nephropathy)
•hepatic failure
•end-stage renal disease
•stroke with cognitive deficiency
•psychotic disorder
•bipolar disorder
•severe substance abuse
•mental retardation
•active infection
•rheumatoid arthritis
•inflammatory bowel disease
•Special Medicines (Hormone Therapy)
•Taking psychotropic drugs
•taking immunosuppressive medications over the past 3 months

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