A phase 2 study of cisplatin plus pemetrexed followed by maintenance pemetrexed in unresectable malignant pleural mesothelioma
- Conditions
- malignant pleural mesothelioma
- Registration Number
- JPRN-UMIN000015226
- Lead Sponsor
- Kyoto Thoracic Oncology Research Group
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 45
Not provided
1) With interstitial pneumonitis or pulmonary fibrosis which chest X-P can detect 2) With fluid accumulation which shoud be treated 3) With active double cancer 4) Patients who had already undergone cisplatin or pemetrexed 5) With poor-controled diabetes mellitus or hypertension 6) With liver cirrhosis diagnosed by imaging findings or clinical findings 7) History of severe heart disease (acute cardiac infarction or unstable angina within 6 months of registration, post-PTCA, post-CABG, sign of heart failure, uncontrollable arrythmia) 8) History of active infection 9) History of pregnancy or lactation 10) Sever drug allergy 11) No consent to blood transfusion 12) Evidence of bleeding tendency 13) No premedication of pemetrexed 14) Those judged to be not suitable by the attending physician
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method progression free survival from induction therapy
- Secondary Outcome Measures
Name Time Method