Maintaining of remifentanil infusion until extubatio

Phase 2

Completed

• Conditions: Condition 1: Craniotomy of supratentorial lesion. Condition 2: Craniotomy of supratentorial lesion. Condition 3: Craniotomy of supratentorial lesion.; Brain, supratentorial; ????? ????? ???

• Registration Number: IRCT2012110711398N1
• Lead Sponsor: Research Deputy of Medicine Faculty, Tehran University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 22 February 2018

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 62

Inclusion Criteria

patients who candidated to supratentorial craniotomy, Age from 18 to 65 years, ASA physical class I-II, preoperative GCS > 13

Eexclusion criteria: age> 65 <18 years, physical class ASA > II, GCS< 13, any allergy to the drugs of study, history of smoking, COPD, chronic cough, asthma, HTN, difficult airway and recent upper respiratory tract infections

Exclusion Criteria

Not provided

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Coughing & bucking intensity. Timepoint: during tracheal extubation. Method of measurement: Minogue Scale.;Mean Arterial Pressure. Timepoint: Each 2 minutes from last skin suture or Mayfield opening until extubation and each 2 minutes after extubation until 10 minute later/each 5 minutes until 15 minute later in recovery room. Method of measurement: Automatic noninvasive sphigmomanumeter.;Heart rate. Timepoint: Each 2 minutes from last skin suture or Mayfield opening until extubation and each 2 minutes after extubation until 10 minute later/each 5 minutes until 15 minute later in recovery room. Method of measurement: Pulse oximeter.

Secondary Outcome Measures

Name	Time	Method
Time interval to awakening after discontinuing of anesthesia drug. Timepoint: Verbal stimulation every min after discontinuing of propofol. Method of measurement: Time to opening of eye with stimulation by cornometer.;Nausea & vomiting pervalance and intensity. Timepoint: Each 15 minutes until 1 hour in recovery room. Method of measurement: Four points score: 1 no sign, 2 mild, 3 moderate, 4 severe.;Concsiousness level. Timepoint: Each 15 minutes until 1 hour in recovery room. Method of measurement: GCS (Glasco coma scale).;Reoperation incidance rate. Timepoint: Till 48 houres after operation. Method of measurement: Sergeon's decision.;Arrythemia incidance rate. Timepoint: After the last suture or Mayfield opening till O.R abondonment. Method of measurement: Contineous ECG monitoring.