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Partial Versus Complete Pulpotomy Using Three Different Materials in Primary Molars: a Clinical Study

Phase 4
Completed
Conditions
Decayed Primary Molars
Interventions
Drug: TheraCal
Drug: Formocresol
Procedure: pulpotomy
Procedure: partial pulpotomy
Registration Number
NCT05190783
Lead Sponsor
Mansoura University
Brief Summary

The purposes of the study to compare partial pulpotomy versus complete pulpotomy in primary molars using three different materials (Formocresol, MTA, Theracal LC) . After 6, 9, 12 and 15 months follow up each case will be evaluated radiographically and clinically. the radiographic criteria to be evaluated are (radiolucency, resorption, widening in periodontal ligament space, Crypt involvement) and clinical criteria are ( pain, tenderness, fistula, abnormal mobility) upon these criteria some recommendations will be made on success and failure rate of each material and each technique.

Detailed Description

In children, deep carious lesions represent the most common disease of primary teeth; 42% of children aged 2 to 11 have dental carious lesions in their primary teeth, with an average of 1.6 decayed teeth per child. The most important objective of pediatric dentistry treatment is the preservation of functional primary teeth until natural exfoliation. In the era of conservative dentistry we are now focusing on repair rather than replacement.

Challenges regarding the best treatment modality in primary molars with deep carious lesions that are free of signs or symptoms have continued over the years. Based on a recent systematic review and a new American Academy of Pediatric Dentistry (AAPD) Guideline for vital pulp therapy in primary teeth, indirect pulp therapy (IPT), direct pulp cap (DPC), and pulpotomy are all viable options for treating the pulp in primary teeth with deep carious lesions.

Partial pulpotomy (PP) was originally a means of preserving the remaining coronal and radicular pulp tissues in permanent teeth after a traumatic pulp exposure. In 1982, Cvek introduced this technique for permanent traumatized teeth with complicated crown fracture, which involved removing two mm of pulp and then dressing the non-inflamed pulp with calcium hydroxide. However, according to the new AAPD best practices recommendation, PP is also indicated in young permanent teeth with a carious pulp exposure in which pulpal bleeding can be controlled within several minutes.

Calcium Hydroxide PP of primary molar teeth with deep carious lesions is used in studies conducted by Schroder and Trairatvorakul. Schroder. showed that the clinical-radiographic success rate of primary molar teeth one year after PP was 83 percent; they concluded that PP has the same favorable outcome as cervical formocresol pulpotomy (FP).

If the pulp is diagnosed as normal or as having reversible pulpitis, a new regenerative material is recommended as the dressing material. In comparison with complete pulpotomy (i.e., removal of the entire pulp chamber), PP has several advantages; it causes limited injury to the pulp and limited loss of tooth substances, and this is important for pulpal healing and easier restoration.

Pulpotomy is the pulp treatment most commonly used for primary teeth with a deep carious lesion approaching the pulp. With pulpotomy, a portion of the pulp is removed: the coronal pulp is removed and the radicular pulp is preserved. After treatment, the cavity is filled with a medicament followed by a final restoration.

Formocresol pulpotomy (FCP) was developed in 1932 by Charles A. Sweet.". The original FCP was a three-appointment procedure which has been reduced to a one-appointment procedure; it is still the most common treatment for primary teeth with caries approaching the pulp.

Studies have shown formocresol therapy to have a success rate between 70% and 90%.Histologic results have been variable in contrast to the high clinical success rate. Formocresol is still considered a gold standard by which all new modalities are compared.

MTA is used in pulp capping whether indirect or directly it has the advantage of biocompatibility to the pulp tissues and stimulates the odontoblast for thicker secondary dentine formation without tunnel defects and formation of hydroxyapatite like material to seal the pulp tissues. Although it has slow setting time, discolor the tooth, relatively high cost compared to the gold stander calcium hydroxide.

TheraCal light Cured (LC) is a single paste calcium silicate-based material promoted by the manufacturer for use as a pulp capping agent and as a protective liner for use with restorative materials, cement, or other base materials. The material might be very likable for clinicians because of its ease of handling. According to Alberto Danga in 2009 the cytotoxic effect of resin-based light-cured (Theracal) on human pulp tissue was least when compared to other materials.

There is a lack of evidence in partial pulpotomy treating primary teeth. In this study a Randomized control trial will be performed to have an evidence based answer for treating primary teeth with partial pulpotomy.

Recruitment & Eligibility

Status
COMPLETED
Sex
All
Target Recruitment
60
Inclusion Criteria
  • No history of spontaneous or nocturnal pain.
  • History of transient pain of sensitivity resulting from various stimuli: hot, cold and sweets.
  • Patient who had a bilateral deep carious lesion at second primary molars.
  • absence of tenderness to percussion
  • absence of physiologic or pathologic tooth mobility
  • Radiographic evidence of no internal or external resorption.
  • There is not an intraradicular or periapical bone loss or widening of the periodontal ligament space.
Exclusion Criteria
  • history of spontaneous or nocturnal pain.
  • Patient who had a unilateral deep carious lesion.
  • presence of tenderness to percussion
  • presence of physiologic or pathologic tooth mobility
  • Radiographic evidence of internal or external resorption.
  • There is an intraradicular or periapical bone loss or widening of the periodontal ligament space.

Study & Design

Study Type
INTERVENTIONAL
Study Design
PARALLEL
Arm && Interventions
GroupInterventionDescription
formocresol pulpotomypulpotomygold standard arm which pulpotomy will be done with formocresol
MTA pulpotomypulpotomyin this group complete pulpotomy will be done with MTA
formocresol partial pulpotomypartial pulpotomypartial pulpotomy will be done with formocresol
pulpotomy with Theracal LCTheraCalin this study group complete pulpotomy will be done with Theracal LC
formocresol pulpotomyFormocresolgold standard arm which pulpotomy will be done with formocresol
pulpotomy with Theracal LCpulpotomyin this study group complete pulpotomy will be done with Theracal LC
formocresol partial pulpotomyFormocresolpartial pulpotomy will be done with formocresol
MTA partial pulpotomypartial pulpotomyin this study group partial pulpotomy will be done with MTA
partial pulpotomy with Theracal LCpartial pulpotomyin this study group partial pulpotomy technique will be done with Theracal LC
partial pulpotomy with Theracal LCTheraCalin this study group partial pulpotomy technique will be done with Theracal LC
MTA partial pulpotomyMTAin this study group partial pulpotomy will be done with MTA
MTA pulpotomyMTAin this group complete pulpotomy will be done with MTA
Primary Outcome Measures
NameTimeMethod
post operative pain15 months

numerical/visual analogue scale 0 no pain 10 worst possible pain

Secondary Outcome Measures
NameTimeMethod
radiolucency15 months

measuring tool is periapical xray

tenderness15 months

percussion test with numerical/visual analogue scale 0 no pain 10 worst possible pain

root resorption15 months

periapical xray

tooth mobility15 months

clinical method of assessing tooth mobility 0 no mobility 3 mobility more than 2 mm bucco-lingualy

widening in periodontal ligament space15 months

periapical xray

fistula15 months

visual inspection

permanent tooth crypt involvement15 months

periapical xray

Trial Locations

Locations (1)

Mansoura University

🇪🇬

Mansoura, Dakahlia, Egypt

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