Diversity Analysis of Vaginal Microbiota on Women With High-risk Human Papillomavirus Infection and Cervical Cytological Abnormalities.
试验速览
- 阶段
- 不适用
- 入组人数
- 151
- 试验地点
- 1
- 主要终点
- Vaginal microbiota and HR-HPV infection
研究概览
简要总结
Since other genital infections enhance HIV susceptibility by inducing inflammation, the investigators study the relationship between the vaginal microbiota composition and the risk of HPV infection, cervical cytological abnormalities.
详细描述
Persistent infection with oncogenic Human Papillomavirus (HPV) is necessary but not sufficient for the development of cervical cancer. Additional factors correlated with HPV persistence include immunodeficiency caused by HIV, smoking, use of oral contraceptives and, more recently reported, vaginal dysbiosis. In a state of dysbiosis, there is a marked reduction of Lactobacillus and a high diversity of bacteria, with increased abundance of anaerobic bacterial species. Based on this, the investigators are going to analyze the changes of microbiota in women with high-risk HPV and the cervical lesions. And the investigators hope to figure out the difference and change in microbiota to realize the tanning of cervical lesions.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 25 Years 至 50 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Clinical diagnosis of HR-HPV results.
排除标准
- •Clinical diagnosis of vaginitis, immune disease, malignancy History of cervical lesions Pregnancy Clinical diagnosis of other serious systemic primary diseases, such as severe liver and kidney dysfunction Severe mental illness
结局指标
主要结局
Vaginal microbiota and HR-HPV infection
时间窗: 12 months
The persistence vaginal organism in HPV infection participants
Vaginal microbiota and the cervical lesion
时间窗: 12 to 36 months
The cervical cytology, HPV and the vaginal microbiota were evaluated
次要结局
未报告次要终点
研究者
shuwang
Associate Professor
Peking Union Medical College Hospital