Single-cell Landscape of BALF in Patients With Severe ARDS and CARDS: an Analysis of the Effectiveness of Steroid Therapy and a Comparison Between COVID-19 ARDS and ARDS From Other Etiologies
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 8
- 试验地点
- 1
- 主要终点
- single-cell analysis in BALF before treatment
研究概览
简要总结
The goal of this observational study is to learn about the effect of steroid therapy in patients with COVID-19 ARDS. The main questions it aims to answer are:
- Differences between patients with COVID-19 ARDS before and after steroid treatment in BALF single cell landscape, as well as patients with different prognosis.
- Differences between COVID-19 and non COVID-19 ARDS patients in BALF single cell landscape.
Participants will Choose whether to use or not to utilize steroid treatment based on conditions.
详细描述
Collect BALF from COVID-19 and non-COVID-19 ARDS patients both before and during remission, then perform single-cell sequencing.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Severe ARDS patients
排除标准
- 未提供
研究组 & 干预措施
COVID-19 with steroid
COVID-19 ARDS patients with steroid treatment
干预措施: steroid (Drug)
non-COVID-19 with steroid
non-COVID-19 ARDS patients with steroid treatment
干预措施: steroid (Drug)
结局指标
主要结局
single-cell analysis in BALF before treatment
时间窗: before treatment in ICU
collect BALF before and during treatment and perform single-cell sequencing
single-cell analysis in BALF after treatment
时间窗: After treatment in ICU for 1-4 weeks
collect BALF before and during treatment and perform single-cell sequencing
次要结局
未报告次要终点