Single-cell Landscape of BALF in Patients With Severe ARDS and CARDS
- Conditions
- Covid19ARDS: Acute Respiratory Distress Syndrome
- Interventions
- Drug: steroid
- Registration Number
- NCT05933291
- Lead Sponsor
- Peking Union Medical College Hospital
- Brief Summary
The goal of this observational study is to learn about the effect of steroid therapy in patients with COVID-19 ARDS. The main questions it aims to answer are:
* Differences between patients with COVID-19 ARDS before and after steroid treatment in BALF single cell landscape, as well as patients with different prognosis.
* Differences between COVID-19 and non COVID-19 ARDS patients in BALF single cell landscape.
Participants will Choose whether to use or not to utilize steroid treatment based on conditions.
- Detailed Description
Collect BALF from COVID-19 and non-COVID-19 ARDS patients both before and during remission, then perform single-cell sequencing.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 8
- Severe ARDS patients
- None
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description non-COVID-19 with steroid steroid non-COVID-19 ARDS patients with steroid treatment COVID-19 with steroid steroid COVID-19 ARDS patients with steroid treatment
- Primary Outcome Measures
Name Time Method single-cell analysis in BALF before treatment before treatment in ICU collect BALF before and during treatment and perform single-cell sequencing
single-cell analysis in BALF after treatment After treatment in ICU for 1-4 weeks collect BALF before and during treatment and perform single-cell sequencing
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Peking Union Medical College Hospital
🇨🇳Beijing, Beijing, China