focal radiotherapy for previously treated prostate cancer patients

Phase 1

Recruiting

• Conditions: locally recurrent prostate cancer following definitive external beam radiotherapy; Cancer - Prostate

• Registration Number: ACTRN12617000035325
• Lead Sponsor: orthern Sydney Local Health District-Royal North Shore Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2017-01-09
• Last Update Posted: 7 June 2021

Recruitment & Eligibility

• Status: Recruiting
• Sex: Male
• Target Recruitment: 36

Inclusion Criteria

1. Men > 4 years (yrs) from previous radiotherapy (RT) meeting the Phoenix definition of biochemical failure or men > 5yrs from RT if neo-adjuvant and/or adjuvant ADT also used
2. Recurrence localised to less than 1 lobe of prostate on both PMSA and multi-parametric MRI (less than equal to cT2a)
3. Recurrence must be biopsy proven, with positive biopsies limited to the PET and MRI suspicious region.
4. Life expectancy at least 10yrs from time of SBRT
5.PSA < 15 (within 2 months prior to enrolment)

Exclusion Criteria

1 Recurrence in immediate proximity to rectum (unless able to have hydrogel)
2 Grade 3 or more toxicity from previous EBRT
3 Contra-indicated for fiducial markers insertion
4 GS 8,9 or 10 disease previously (relative - consider if decent disease free interval)

Study & Design

• Study Type: Interventional
• Study Design: Not specified