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Clinical Trials/NCT01280019
NCT01280019
Unknown
Phase 4

Functional Residual Capacity Guided Alveolar Recruitment Strategy in Patients With Acute Respiratory Failure After Cardiac Surgery

University of Luebeck1 site in 1 country20 target enrollmentOctober 2010

Overview

Phase
Phase 4
Intervention
Not specified
Conditions
Mechanical Ventilation
Sponsor
University of Luebeck
Enrollment
20
Locations
1
Primary Endpoint
Regional ventilation
Last Updated
15 years ago

Overview

Brief Summary

In ventilated patients with acute respiratory failure endotracheal suctioning may lead to alveolar derecruitment, which can be monitored by means of functional residual capacity (FRC) measurements. Regional distribution of ventilation can be followed at bedside using electrical impedance tomography. The investigators hypothesize that a FRC guided recruitment strategy, aimed at restoring a baseline FRC value after open endotracheal suctioning, improves oxygenation and regional distribution of ventilation. In addition the investigators research the impact of such a strategy on the inflammatory response to mechanical ventilation.

Registry
clinicaltrials.gov
Start Date
October 2010
End Date
May 2012
Last Updated
15 years ago
Study Type
Interventional
Study Design
Parallel
Sex
All

Investigators

Sponsor
University of Luebeck

Eligibility Criteria

Inclusion Criteria

  • need for mechanical ventilation due to respiratory failure after cardiac surgery

Exclusion Criteria

  • circulatory failure, eg. need for high doses of inotropes or extracorporal cardiac support

Outcomes

Primary Outcomes

Regional ventilation

Time Frame: 6 hours

Regional distribution of ventilation over 6 hours of treatment

Secondary Outcomes

  • arterial oxygenation and inflammation(6 hours)

Study Sites (1)

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