FRC Guided Therapy in Acute Respiratory Failure

Phase 4

• Conditions: Mechanical Ventilation; Acute Respiratory Failure; Cardiac Surgery
• Interventions: Procedure: alveolar recruitment manoeuvre

• Registration Number: NCT01280019
• Lead Sponsor: University of Luebeck

Brief Summary

In ventilated patients with acute respiratory failure endotracheal suctioning may lead to alveolar derecruitment, which can be monitored by means of functional residual capacity (FRC) measurements. Regional distribution of ventilation can be followed at bedside using electrical impedance tomography. The investigators hypothesize that a FRC guided recruitment strategy, aimed at restoring a baseline FRC value after open endotracheal suctioning, improves oxygenation and regional distribution of ventilation. In addition the investigators research the impact of such a strategy on the inflammatory response to mechanical ventilation.

Detailed Description

Not available

Study Timeline

• Study Start: 2010-10
• Status Verified: 2011-01
• Study First Submitted: 2011-01-19
• Study First Submitted QC: 2011-01-19
• Last Update Submitted: 2011-01-19
• Study First Posted: 2011-01-20
• Last Update Posted: 2011-01-20
• Primary Completion: 2011-12
• Study Completion: 2012-05

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• need for mechanical ventilation due to respiratory failure after cardiac surgery

Exclusion Criteria

• circulatory failure, eg. need for high doses of inotropes or extracorporal cardiac support

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
FRC guided	alveolar recruitment manoeuvre	Patients receive an alveolar recruitment manoeuvre if FRC falls below 94% of baseline FRC
Saturation guided	alveolar recruitment manoeuvre	Patients receive an alveolar recruitment manoeuvre if peripheral oxygen saturation falls below 90%

Primary Outcome Measures

Name	Time	Method
Regional ventilation	6 hours	Regional distribution of ventilation over 6 hours of treatment

Secondary Outcome Measures

Name	Time	Method
arterial oxygenation and inflammation	6 hours	Changes of arterial oxygenation and inflammatory parameters in the blood during 6 hours of treatment

Trial Locations

Locations (1)

Department of Anaesthesiology, Intensive Care Unit, University of Lübeck; 🇩🇪 Lübeck, Germany