The Effect of Soluble Fiber Dextrin on Subjective and Physiological Markers of Appetite

Not Applicable

Completed

• Conditions: Appetitive Behavior
• Interventions: Other: Soluble Fiber Dextrin

• Registration Number: NCT04596969
• Lead Sponsor: Iowa State University

Brief Summary

This study examines the effect of soluble fiber dextrin on food intake, appetite, and physiological markers of appetite. Adults aged 18-45 years with a BMI were recruited for this study. Participants were given two doses of SFD in the morning and appetite, food intake and physiological markers of appetite were measured over 10 years.

Detailed Description

Overweight and obesity are leading health problems. The study investigates the effect of a food ingredient from two different sources at two different doses on food intake and appetite markers over a 10 hour period. All participants reported to the laboratory first thing in the morning and remained in the laboratory until after their evening meal. A fixed breakfast was served but the participants were free to eat as much as they liked at lunch and dinner. Blood was taken at regular intervals during the day and assayed for glucose and several hormones related to appetite. Subjective measures of appetite were also collected over the 10 hour test session.

Study Timeline

• Study Start: 2014-01-01
• Primary Completion: 2017-01-01
• Study Completion: 2018-01-01
• Status Verified: 2020-09
• Study First Submitted: 2020-10-15
• Study First Submitted QC: 2020-10-15
• Last Update Submitted: 2020-10-15
• Study First Posted: 2020-10-22
• Last Update Posted: 2020-10-22

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

BMI 19.9 - 29.9 Aged 18-45 Find the study foods to be palatable

Exclusion Criteria

Weight change > 3kg in the past three months Do not regularly consume snacks Presence or history of GI disorders Restrained eater Used medication that influences appetite

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Control	Soluble Fiber Dextrin	Maltodextrin
SFD corn 20g	Soluble Fiber Dextrin	40g soluble fiber dextrin derived from corn
SFD Tapioca 20g	Soluble Fiber Dextrin	20g soluble fiber dextrin derived from tapioca
SFD Tapioca 40g	Soluble Fiber Dextrin	40g soluble fiber dextrin derived from tapioca
SFD corn 40g	Soluble Fiber Dextrin	-

Primary Outcome Measures

Name	Time	Method
Food intake	10 hours	Food intake measured at lunch and evening meal.

Secondary Outcome Measures

Name	Time	Method
Appetite	10 hours	Subjective appetite measures using questionnaires at regular intervals over 10 hours,
CCK	10 hours	Plasma CCK measured at regular intervals over 10 hours.
GLP-1	10 hours	Plasma GLP-1 measured at regular intervals over 10 hours.
PYY3-36	10 hours	Plasma PYY3-36 measured at regular intervals over 10 hours.
Breath Hydrogen	10 hours	Breath hydrogen measured at regular intervals over 10 hours.