Effects of Dexmedetomidine on Delirium After Living Donor Renal Transplantation in Adult Patients

Phase 4

• Conditions: Postoperative Delirium After Living Donor Renal Transplantation
• Interventions: Drug: Dexmedetomidine; Drug: Saline

• Registration Number: NCT02509949
• Lead Sponsor: Tao Zhang

Brief Summary

Delirium, an acute change in mental status, is a serious medical complication among hospitalized patients. Syndrome of delirium involves agitation, sleep disturbance, affective disorders and cognitive disruptions.

One vulnerable period for developing delirium is in the postoperative days. Postoperative delirium often initiates a cascade of adverse consequences including an increase in length of stay and hospital costs, and greater mortality. The investigators have observed that the incidence of postoperative delirium in patients after renal transplantation is about 20-30% in our hospital.

Several studies have revealed that dexmedetomidine, as a widely used sedative during anesthesia, can decrease the incidence of postoperative delirium after cardiac surgery. The investigators aim to examine whether administration of dexmedetomidine can reduce postoperative delirium after living donor renal transplantation in adult patients.

Detailed Description

Not available

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study Start: 2015-05
• Study First Submitted: 2015-07-24
• Study First Submitted QC: 2015-07-27
• Study First Posted: 2015-07-28
• Status Verified: 2018-06
• Last Update Submitted: 2018-06-09
• Last Update Posted: 2018-06-12
• Primary Completion: 2019-09

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• age > 17 and < 60 years;
• American Society of Anesthesiology (ASA) I-III;
• admitted for living donor renal transplantation.

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Exclusion Criteria

• Patients with a history of drug abuse;
• preoperative history of schizophrenia, epilepsy, parkinsonism, use of cholinesterase inhibitor, inability to communicate in the preoperative period (coma, profound dementia, or language barrier).

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Dexmedetomidine	Dexmedetomidine	Dexmedetomidine ivpump 0.2ug/kg/h during living donor renal transplantation.
Saline	Saline	Saline ivpump 0.2ug/kg/h during living donor renal transplantation.

Primary Outcome Measures

Name	Time	Method
Postoperative Delirium	Postoperative day 1-7.

Trial Locations

Locations (1)

First Affiliated Hospital, Sun Yat-Sen University; 🇨🇳 Guangzhou, Guangdong, China