Effect of Static vs. Conversational AI-Generated Messages on Colorectal Cancer Screening Intent: a Randomized Controlled Trial
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 915
- 试验地点
- 2
- 主要终点
- Change in Self-Reported Likelihood of Completing Stool Test Screening for Colorectal Cancer
研究概览
简要总结
The goal of this clinical trial is to assess whether messages generated by a large language model (LLM), including both static and conversational formats, can increase colorectal cancer (CRC) screening intentions among U.S. adults aged 45-75 who have never completed CRC screening. The main questions it aims to answer are:
Do personalized, AI-generated messages increase the self-reported likelihood of completing a stool-based CRC screening test within 12 months?
Do they also increase intent to undergo colonoscopy screening within 12 months?
Researchers will compare four groups: (1) no message control, (2) expert-written patient education materials, (3) a single AI-generated persuasive message, and (4) a motivational interviewing-style AI chatbot. These comparisons will help assess whether a conversational format offers added benefit over static AI or expert-generated content.
Participants will:
Be randomly assigned to one of the four study arms
Spend at least 3 minutes reading or interacting with their assigned material
Complete pre- and post-intervention surveys assessing intent to receive CRC screening
Receive messages tailored to their self-reported demographics, including age, political ideology, gender, education, community setting (urban, rural, suburb), self-reported health, and the last time they saw their PCP
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Screening
- 盲法
- None
入排标准
- 年龄范围
- 45 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Adults aged 45 to 75 years
- •Currently residing in the United States
- •Self-reported no prior colorectal cancer screening (or unsure if screened)
- •Able to read and understand English
- •Consent to participate in a behavioral research study
排除标准
- •Previous colonoscopy, stool test, sigmoidoscopy, or CT colonography
- •Failure to pass pre- or post-intervention attention checks
- •Identified as non-human respondents by reCAPTCHA or other automated bot detection
- •Completion time significantly shorter than the median, indicating inattentiveness
研究组 & 干预措施
AI Motivational Interviewing Chatbot
The motivational interviewing chatbot refers to a GPT-4.1 based chatbot that has been instructed to follow motivational interviewing principals to persuade participants to get screened for CRC.
干预措施: AI Chatbot (Behavioral)
single GPT generated message
The single GPT generated message is a single ~640 word persuasive message generated by GPT-4.1 where GPT-4.1 is provided with the same self-reported demographics.
干预措施: single GPT generated message (Behavioral)
CRC JAMA patient page
The 642 word JAMA Patient Page contains up to date information on screening guidelines for CRC directed at patients.
干预措施: Expert-Written Patient Materials (Behavioral)
No Message
Participants read a ~640 word fictional short story about a cat and dog.
结局指标
主要结局
Change in Self-Reported Likelihood of Completing Stool Test Screening for Colorectal Cancer
时间窗: Immediately before and after the intervention (single session; same day)
Measured on a 0-100 scale, where 0 = "Extremely unlikely" and 100 = "Extremely likely." Assessed before and after the intervention. Change in score indicates difference in participant intention to complete a stool-based CRC screening test.
Change in Self-Reported Likelihood of Completing Colonoscopy Screening for Colorectal Cancer
时间窗: Immediately before and after the intervention (single session; same day)
Measured on a 0-100 scale, where 0 = "Extremely unlikely" and 100 = "Extremely likely." Assessed before and after the intervention. Change in score reflects shift in participant intention to complete a colonoscopy within the next 12 months.
Change in Self-Reported Likelihood of Completing Stool Test Screening for Colorectal Cancer
时间窗: Immediately before and after the intervention (single session; same day)
Measured on a 0-100 scale, where 0 = "Extremely unlikely" and 100 = "Extremely likely." Assessed before and after the intervention. Change in score indicates difference in participant intention to complete a stool-based CRC screening test.
Change in Self-Reported Likelihood of Completing Colonoscopy Screening for Colorectal Cancer
时间窗: Immediately before and after the intervention (single session; same day)
Measured on a 0-100 scale, where 0 = "Extremely unlikely" and 100 = "Extremely likely." Assessed before and after the intervention. Change in score reflects shift in participant intention to complete a colonoscopy within the next 12 months.
次要结局
- Perceived Empathy of the Intervention(Immediately after the intervention (single session))
- Comfort Discussing CRC Screening with a Provider(Immediately before and after the intervention (single session; same day))
- Perceived Message Effectiveness(Immediately after the intervention (single session))
- Change in Reasons for CRC Screening Hesitancy(Immediately before and after the intervention (single session))
- Perceived Empathy of the Intervention(Immediately after the intervention (single session))
- Comfort Discussing CRC Screening with a Provider(Immediately before and after the intervention (single session; same day))
- Perceived Message Effectiveness(Immediately after the intervention (single session))
- Change in Reasons for CRC Screening Hesitancy(Immediately before and after the intervention (single session))