NCT02885818已完成不适用
Does Abatacept Induce Regulatory B Cells in Patients With Rheumatoid Arthritis
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- Peripheral blood B-cell phenotype changes
研究概览
简要总结
Abatacept disrupts T-cell coactivation signals in rheumatoid arthritis (RA). Its potential effects on B cells are not well described. This study will assess the effects of abatacept therapy on the phenotype and function of peripheral blood B cells in patients with RA.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •RA as defined by ACR/EULAR criteria
- •Clinical indication to start abatacept therapy
排除标准
- •Treatment by rituximab in the previous year
结局指标
主要结局
Peripheral blood B-cell phenotype changes
时间窗: 3 months
Measure of the proportion of the main B-cell subsets (transitional, naïve, memory, plasmablasts) by FACS analysis before abatacept initiation and 3 months later.
次要结局
- In vitro B-cell function and regulatory properties(3 months)
研究者
研究点 (1)
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