Efficacy of Ayurveda Protocol on Rheumatoid Arthritis - A Randomized Controlled Clinical trial

Rheumatoid arthritis is a chronic progressive immune inflammatory systemic disease that effect mainly the synovial joint , with a possibility of extra articular manifestations. Rheumatoid is a chronic multisystem disease of unknown cause. It typically starts in small peripheral joints, is usually symetric and progresses to involve proximal joints if left untreated. Untreated rheumatoid arthritis can cause severe damage to the joints and their surrounding tissue. It can lead to heart , lung and nervous system problems. In 2019 , 18 million people worldwide were living with rheumatoid arthritis with female male ratio of 3:1 projected to the whole population this would give a total of about seven million patients in India . The current therapy used to treat rheumatoid arthritis include non steroidal anti inflammatory drugs disease modifyng antirheumatic drugs DMARDS used for a first line therapy for all newly diagnosed cases of rheumatoid arthritis and biological response modifiers, target agents that selectively inhibit specific molecules of the immune system . These medication are similar in their adverse effect so , early and continuous use of DMARDs is necessary to slow joint damage and improve long term outcome .Unfortunately , long term treatment with these drugs is frequently limited the loss of response and/or onset of serious adverse events .

the classical clinical feature of amavata are closely mimic to the features of rheumatoid arthritis .Ama is a the condition in which various ailments in system create toxic effect . The ama when combines with vata dosha and occupies sheleshmasthana (asthisandhi) results in painful disease called amavata . In the management of amavata sequential employment of dipana ,amapachana, shodhan and shaman therapies have been mentioned . various treatment protocol like vaitarana basti , anuvasana basti , valuka sweda with shamana medicines like simhanada guggulu , rasana saptaka kashaya etc. have been mentioned in the classics which are being used to treat the condition. As proved in recent studies bio marker IL-6 was found to be elevated in serum as well as synovial fluid of patients with rheumatoid arthritis hence to know the efficacy of ayurveda treatment on rheumatoid arthritis . This idea as a whole , plan for furthur study is made for the better outcome in patients health .