NEAT - Prevention and Treatment of Overweight and Obesity.

Not Applicable

Completed

• Conditions: Obesity; Overweight
• Interventions: Behavioral: Health talk; Behavioral: Treadmill workstation

• Registration Number: NCT01997970
• Lead Sponsor: Umeå University

Brief Summary

This study will investigate the effect on Non-exercise Activity Thermogenesis (NEAT) when implementing active workstation at offices compared to conventional office work. The primary hypothesis is that this implementation will lead to a significant increase in time spent walking per day.

Detailed Description

NEAT consists of the energy expenditure of the physical activities that are non sporting-like and that we perform in our everyday life, such as walking, cleaning, shoveling snow etc. Which occupation we have play a big role in how much we are able to active our NEAT during our days and those who have more active jobs can expend up to 1500kcal more per day than those with sedentary jobs.

This study aims to try and increase NEAT at offices where sedentary time often is high. Participants will be randomized to either an intervention group or to a control group. Participants in the control group will continue to work at their regular desk, but will receive an individual health talk in the beginning of the study where diet and physical activity recommendations will be discussed.Participants in the intervention group will receive the same individual health talk and a treadmill desk, which they will use for 12 months at self-selected speed. They will be recommended to walk on the treadmill for at least 1 hour per day.

Study Timeline

• Study First Submitted: 2013-11-02
• Study First Submitted QC: 2013-11-22
• Study First Posted: 2013-11-28
• Study Start: 2014-02
• Primary Completion: 2015-12
• Study Completion: 2015-12
• Status Verified: 2016-05
• Last Update Submitted: 2016-05-10
• Last Update Posted: 2016-05-12

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

• Office workers with mainly sedentary tasks
• BMI 25-40

Exclusion Criteria

• Severe depression and/or anxiety
• Exhaustion disorder
• Diabetes Mellitus
• Severe cardiovascular disease
• Severe kidney disease
• Musculoskeletal disorders that prohibit walking on a treadmill
• Contraindications for physical activity
• Thyroidea illness
• Pregnancy

For fMRI-study, additional exclusion criteria are:

• Implanted metal- or electrical devices
• Pregnancy
• Extraneous metal pieces in the body

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Control group	Health talk	Will receive a health talk with recommendations about diet and physical activity habits. Will continue to work with conventional office work at their regular desk.
Treadmill workstation	Treadmill workstation	Will receive a health talk with recommendations about diet and physical activity habits and will also receive a treadmill workstation at regular office site for 12 months.
Treadmill workstation	Health talk	Will receive a health talk with recommendations about diet and physical activity habits and will also receive a treadmill workstation at regular office site for 12 months.

Primary Outcome Measures

Name	Time	Method
Change from baseline in physical activity and sedentariness at 12 months	Baseline, 12 months	Measured with an accelerometer (ActiGraph) and an inclinometer (ActivPAL).

Secondary Outcome Measures

Name	Time	Method
Change from baseline in metabolism at 12 months	Baseline, 12 months	Metabolism: 2h glucose tolerance test. lipids, Hb1Ac
Change from baseline in anthropometrics at 12 months	Baseline, 12 months	Length, height, weight, waist circumference, hip circumference, sagittal height, pulse, blood pressure.
Change from baseline in body composition at 12 months	Baseline, 12 months	Measured with Dual X-Ray Absorptiometry (DXA)
Change from baseline in musculoskeletal pain at 12 months	Baseline, 12 months	Measured with the Chronic Pain Grade Questionnaire
Change from baseline in stress at 12 months	Baseline, 12 months	Measured by assessing cortisol levels in the saliva at 4 time points during one day. Also measured with the stress- and energy scale.
Change from baseline in Quality of Life at 12 months	Baseline, 12 months	Measured with 2 questions from the SF-36.
Change from baseline in cognitive Function and functional brain response at 12 months	Baseline, 12 months	Measured with a cognitive test battery and functional MRI (fMRI). Levels of Brain-Derived Neurotrophic Factor (BDNF) is measured in the plasma.
Change from baseline in depression/anxiety at 12 months	Baseline, 12 months	Measured with the Hospital Anxiety and Depression Scale.
Qualitative interview study	12 months	Participants will be interviewed about experiences from being part of the study and about attitudes and factors that influences them to be physically active.

Trial Locations

Locations (1)

Umeå University; 🇸🇪 Umeå, Sweden