Lymph Node Staging System With a Novel Concept for Gastric Cancer: a Hybrid Type of Topographic and Numeric Ones
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 6,025
- 试验地点
- 1
- 主要终点
- Prognostic performance
研究概览
简要总结
For staging the status of lymph node metastasis in gastric cancer, typographic based staging system was applied until last decade, especially in Eastern countries. However the old typographic lymph node staging system in gastric cancer was too complicated and less accurate for predicting the prognosis. Now the numeric based lymph node staging system is used in both East and West, but it include problems: no information on the anatomical extent of the disease, preoperative lymph node staging is nearly impossible, failure to provide an appropriate treatment plan, cannot represent the extent of lymph node dissection. We designed simple and specifically representing the anatomic extent of the disease for staging the status of lymph node in gastric cancer. Thus we compared its prognostic performance of this new staging system with those of the current TNM 7th edition of AJCC/UICC.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients were pathologically confirmed as primary gastric cancer
- •patients underwent gastrectomy with curative intent.
排除标准
- •Patients underwent minimally invasive surgery
- •patients with any distant metastases including peritoneal seeding and para-aortic LNs metastasis)
- •when the location of lymph nodes were not divided
- •patients underwent chemotherapy preoperatively
- •patients had metastatic lymph nodes with unclear location
结局指标
主要结局
Prognostic performance
时间窗: participants will be followed for the duration of survival, an expected average of 36 months.
The overall survival (OS) was used to evaluate the prognosis after gastrectomy. The Kaplan-Meier method and log-rank test were applied to analyze the OS. In addition, the Cox proportional hazards model was used to estimate hazard ratios (HRs). To compare the discrimination of each stage, the Kaplan-Meier curves from each stage in both staging systems was used. For comparing prognostic performance of each staging system, Harrell C-index (for measuring the predictive accuracy of survival outcome) were used.
次要结局
未报告次要终点