Evaluation of the interference in the immunity caused by anesthetics Sevoflurane versus Propofol in intraoperative obese patients (obesita): study protocol for a randomized clinical trial

Not Applicable

• Conditions: obesity due to excess calories; morbid obesity.; E66.0; C18.654.726.500.700

• Registration Number: RBR-77kfj5
• Lead Sponsor: Rede D'Or Sao Luiz S.A.

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2018-08-30
• Last Update Posted: 29 May 2023

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: Not specified
• Target Recruitment: Not specified

Inclusion Criteria

Age range 18 to 59 years; body mass index greater than or equal to 35 kilograms per square meter; signature of the free and informed consent form.

Exclusion Criteria

Patients with insulin; anti-inflammatory and / or immunosuppressive therapies; diagnosis of malignant disease; chronic kidney disease, with KDOQI greater than 3; chronic liver disease, with total serum protein less than 3 grams per deciliter and total bilirubin greater than 5 milligrams per deciliter; heart disease, with NYHA III or IV; obesity caused by endocrine disorder; patients with psychiatric illness that may interfere with the capacity for formal consent and compliance; persistent smoking associated with significant obstructive or restrictive lung disease, with vital capacity or forced expiratory volume in one second less than 50% of predicted value; alcohol dependence; pre-existing coagulation disorders; evident pulmonary or systemic infection, with clinically defined or increased C reactive protein above 5 milligrams per ml, leukocytosis greater than 10,000, or body temperature greater than 37 Celsius; presence of autoimmune diseases; participated in another randomized clinical trial in the last year.

Study & Design

• Study Type: Intervention
• Study Design: Not specified