NCT04912193已完成不适用
Low Preoperative Antithrombin III Level is Associated With Postoperative Acute Kidney Injury After Liver Transplantation
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 2,395
- 试验地点
- 1
- 主要终点
- acute kidney injury
研究概览
简要总结
The reno-protective effect of Antithrombin III (ATIII) has been well-studied in various animal studies; however, little is known about the effect of ATIII on kidney function in patients undergoing liver transplantation (LT). This study aimed to determine the association between preoperative ATIII level and postoperative acute kidney injury (AKI) after LT (post-LT AKI).
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Other
入排标准
- 年龄范围
- 19 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients who underwent either living- or deceased-donor LT (LDLT, DDLT) from January 2010 to January 2018
排除标准
- •patients who underwent re-transplantation
- •patients who were previously diagnosed with end-stage renal disease or Chronic kidney disease
- •patients who were being treated with continuous renal replacement therapy
- •preoperative or postoperative Antithrombin III levels were not available
研究组 & 干预措施
antithrombin III < 50 %
preoperative antithrombin III levels <50%
干预措施: Antithrombin III (Drug)
结局指标
主要结局
acute kidney injury
时间窗: postoperative 7 day
serum creatinine \>0.3 mg/dL within POD 2 or increase by \>1.5 times within POD 7 according to the criteria set by the Kidney Disease: Improving Global Outcomes (KDIGO) classification
次要结局
- chronic kidney disease(postoperative 3 months)
- early allograft dysfucion(postoperative 7 day)
研究者
Kyoung-Sun Kim
Senior Clinical Fellow
Asan Medical Center
研究点 (1)
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