A pilot study on magnetic resonance imaging of the distal radial growth plate: defining healthy and pathologic characteristics in a non-invasive manner
- Conditions
- gymnast wristradial epiphysitis10005959
- Registration Number
- NL-OMON43849
- Lead Sponsor
- Academisch Medisch Centrum
- Brief Summary
Trial ended prematurely
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 69
Symptomatic gymnast group:
- Age range 12-18 years;
- Open radial growth plate on hand radiograph;
- Gymnastics participation in six months before inclusion, for duration a period of at least one year and up to six months or less before moment of inclusion in the study;
- Wrist pain in past 6 months;
- Written informed consent by participant;
- Written parental consent.;Asymptomatic gymnast group:
- Age range 12-18 years;
- Open radial growth plate on hand radiograph;
- Gymnastics participation for a period of at least one year and up to six months or less before moment of inclusion in the study;
- No wrist pain in past 6 months;
- Written informed consent by participant;
- Written parental consent.;Non-gymnast control group:
- Age range 12-18 years;
- Open radial growth plate on hand radiograph;
- No gymnastic participation at present or in the past;
- No participation of other wrist-loading sport with risk of wrist overuse injury (i.e. racquet sports, volleyball, field hockey, rowing, judo) for more than twice a week;
- No history of wrist trauma, such as wrist fracture;
- Written informed consent by participant;
- Written parental consent.
- History of past fracture, infection or surgery of the wrist;
- Diagnosed with any growth disorder;
- Diagnosed with systemic disease involving the musculoskeletal system (e.g. juvenile idiopathic arthritis);
- Oncological disease involving the musculoskeletal system;
- Fully closed growth plate on wrist radiographs, indicative of skeletal maturation;
- No written informed consent.
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Early signs of growth plate injury on conventional radiographs, standard MRI<br /><br>sequences and on MRI sequences sensitive for cartilage imaging, such as oedema,<br /><br>bony bridges and growth plate widening;</p><br>
- Secondary Outcome Measures
Name Time Method <p>- Skeletal age as determined from a hand radiograph;<br /><br>- Signs of distal radial growth plate injury on hand radiographs, such as<br /><br>widening and haziness of the growth plate;<br /><br>- Quantification of growth plate pathology on DWI MR images using ADC maps;<br /><br>- Growth plate volume derived from 3D mapping;<br /><br>- Growth plate thickness;<br /><br>- Clinical signs and severity of distal radial growth plate injury such as<br /><br>wrist pain;<br /><br>- Anthropomorphic characteristics (length, weight) and training characteristics<br /><br>(starting age, level, training intensity in hours, training frequency in days,<br /><br>specialty elements) of participants.</p><br>