ISRCTN88528808CompletedNot Applicable
Angiotensin II-Antagonist in Paroxysmal Atrial Fibrillation Trial
German Atrial Fibrillation Network0 sites422 target enrollmentStarted: October 4, 2005Last updated:
Conditions
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Enrollment
- 422
Study Overview
Brief Summary
No summary available.
Study Design
- Study Type
- Interventional
Eligibility Criteria
- Sex
- All
Inclusion Criteria
- •1. Documented paroxysmal atrial fibrillation: electrocardiogram (ECG) documentation of atrial fibrillation at least
- •in one ECG recorded during the last 2 months prior to randomization plus additional ECG recording of sinus rhythm at least 12 hours after the above mentioned ECG documentation
- •2. Age =18
- •3. Patient informed orally and in writing
- •4. Written informed consent of the patient
Exclusion Criteria
- •1. Strong clinical evidence for therapy with AT II/ACE inhibitors within the last month
- •2. Therapy with antiarrhythmic agents of class I or class III within the last month, therapy with amiodaron within the last 3 months
- •3. DC cardioversion within the last 3 months
- •4. Symptomatic bradycardia
- •5. Implanted pacemaker or implanted cardioverter/defibrillator with any antitachycardiac algorithm in use
- •6. Cardiac surgery or cardiac catheter ablation within the last 3 months
- •7. Typical angina pectoris symptoms at rest or during exercise
- •8. Known coronary artery disease with indication for intervention
- •9. Valvular disease >II degree
- •10. Left ventricular ejection fraction <40%
- •11. Diastolic blood pressure >110 mmHg at rest
- •12. Symptomatic arterial hypotension
- •13. Known renal artery stenosis
- •14. Serum creatinine >1.8 mval/l
Investigators
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