The 'Hidden' Biological Impact of Vitamin D Deficiency: a Biomarker Study; Part 2
- Conditions
- Vitamin D Deficiency
- Interventions
- Dietary Supplement: Vitamin D
- Registration Number
- NCT02451787
- Lead Sponsor
- The Hong Kong Polytechnic University
- Brief Summary
The investigators major aims are to: determine the vitamin D status of a group of young, apparently healthy adults in Hong Kong; examine inter-relationships between vitamin D status and biomarkers of DNA damage and repair, oxidative stress, inflammation and endothelial health; and, in part 2 of the study, investigate effects of improvement in vitamin D status on these biomarkers and other measures of well-being in those young adults shown to be deficient in vitamin D.
- Detailed Description
In this part 2 of the study the investigators will investigate the effect of vitamin D supplementation on biomarkers of these 'hidden' changes in apparently healthy young adults. The investigators will also explore the effect of improvement in vitamin D status in young apparently healthy adults in regard to muscular strength and response time, glucose control, a hormone that is linked to vitamin D (parathyroid hormone (PTH) ) and mood.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 27
- apparently healthy, non-smokers
- non-obese
- found (in part1) to have low vitamin D status
- chronic illness
- serious illness requiring medical treatment in previous 6 months
- pregnancy
- on regular medication or taking supplements on a regular basis
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Active Vitamin D vitamin D supplementation group (2500 IU day for 3 months) Control Vitamin D no vitamin D supplementation
- Primary Outcome Measures
Name Time Method biomarkers of oxidative stress 3 months
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
The Hong Kong Polytechnic University
ðŸ‡ðŸ‡°Hong Kong, Hong Kong