The 'Hidden' Biological Impact of Vitamin D Deficiency: a Biomarker Study
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 入组人数
- 27
- 试验地点
- 1
- 主要终点
- biomarkers of oxidative stress
研究概览
简要总结
The investigators major aims are to: determine the vitamin D status of a group of young, apparently healthy adults in Hong Kong; examine inter-relationships between vitamin D status and biomarkers of DNA damage and repair, oxidative stress, inflammation and endothelial health; and, in part 2 of the study, investigate effects of improvement in vitamin D status on these biomarkers and other measures of well-being in those young adults shown to be deficient in vitamin D.
详细描述
In this part 2 of the study the investigators will investigate the effect of vitamin D supplementation on biomarkers of these 'hidden' changes in apparently healthy young adults. The investigators will also explore the effect of improvement in vitamin D status in young apparently healthy adults in regard to muscular strength and response time, glucose control, a hormone that is linked to vitamin D (parathyroid hormone (PTH) ) and mood.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 26 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •apparently healthy, non-smokers
- •non-obese
- •found (in part1) to have low vitamin D status
排除标准
- •chronic illness
- •serious illness requiring medical treatment in previous 6 months
- •pregnancy
- •on regular medication or taking supplements on a regular basis
研究组 & 干预措施
Active
vitamin D supplementation group (2500 IU day for 3 months)
干预措施: Vitamin D (Dietary Supplement)
Control
no vitamin D supplementation
干预措施: Vitamin D (Dietary Supplement)
结局指标
主要结局
biomarkers of oxidative stress
时间窗: 3 months
次要结局
未报告次要终点
研究者
Iris BENZIE
Chair Professor
The Hong Kong Polytechnic University