Randomized Clinical Trial on Epidural Analgesia Versus Patient-controlled Analgesia Using Acetaminophen for Laparoscopic Colorectal Surgery
- Conditions
- Patients undergoing laparoscopic colorectal surgery
- Registration Number
- JPRN-UMIN000022190
- Lead Sponsor
- Kitasato University
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 80
Not provided
Subjects are excluded from the study by the following criteria. The investigator must ensure the criteria at the time of enrollment unless otherwise specified. 1) Any subjects with a past history of anaphylaxis due to acetaminophen. 2) Any subjects contraindicated to use acetaminophen. 3) Any subjects with conditions of severe hepatic, renal, and heart dysfunction, and infections. 4) Any subjects assumed to be adversely affected by pharmacological effects of acetaminophen. 5) Any subjects assumed to have difficulty in epidural analgesia. 6) Any subjects with high possibility of need for abdominal surgery during laparoscopic colorectal surgery. 7) Any subjects judged not eligible for enrollment of the study other than any of the above reasons by the investigator.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Medical recovery is determined by the following criteria. 1. Recovery of motor function (period of time required for the status at least comparable with the one in preoperative time, or period of time required for the first time walking after surgery) 2. Recovery of the function of digestive system (period of time required for the first time feces and flatus after surgery). 3. Pain control (period of time required for the switch to oral analgesia, and the number of time subjects use analgesics)
- Secondary Outcome Measures
Name Time Method 1. Influence on inflammatory response following laparoscopic colorectal surgery 2. Adverse effect