An Open-label Study Of MDX-CTLA4 In Combination With Tyrosinase/gp100/MART-1 Peptides Emulsified With Montanide ISA 51 In The Treatment Of Patients With Resected Stage III Or Stage IV Melanoma
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 入组人数
- 19
- 试验地点
- 1
研究概览
简要总结
RATIONALE: Monoclonal antibodies can locate tumor cells and either kill them or deliver tumor-killing substances to them without harming normal cells. Vaccines made from a person's cancer cells may make the body build an immune response to kill tumor cells.
PURPOSE: Phase I trial to study the effectiveness of combining monoclonal antibody therapy and vaccine therapy in treating patients who have stage III or stage IV melanoma that has been removed during surgery.
详细描述
OBJECTIVES:
- Determine the safety and adverse event profile of anti-cytotoxic T-lymphocyte-associated antigen-4 monoclonal antibody combined with tyrosinase:368-376, gp100:209-217, and MART-1:26-35 peptides emulsified in Montanide ISA-51 in patients with resected stage III or IV melanoma.
- Determine if this regimen causes antigen-specific T-cell activation in these patients.
- Determine the clearance profile of this regimen in these patients.
- Assess the development of host immune response in patients treated with this regimen.
OUTLINE: This is a dose-escalation study of anti-cytotoxic T-lymphocyte-associated antigen-4 monoclonal antibody (MDX-CTLA4).
Patients receive tyrosinase:368-376, gp100:209-217, and MART-1:26-35 peptides emulsified in Montanide ISA-51 subcutaneously followed by MDX-CTLA4 IV over 90 minutes at 0, 1, 2, 3, 4, 5, 8, and 11 months in the absence of disease progression or unacceptable toxicity.
Cohorts of at least 6 patients receive escalating doses of MDX-CTLA4 until the maximum tolerated dose is determined.
研究设计
- 研究类型
- Interventional
- 主要目的
- Treatment
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •DISEASE CHARACTERISTICS:
- •Histologically confirmed completely resected stage III or IV melanoma
- •Mucosal or ocular subtypes allowed
- •HLA-A2 positive
- •Positive staining of tumor tissue with antibody HMB-45 for gp100, tyrosinase, and/or MART-1
- •Failed (or ineligible for or refusal of) interferon alfa
- •PATIENT CHARACTERISTICS:
- •Not specified
- •Performance status:
- •Karnofsky 60-100%
- •Life expectancy:
- •At least 12 months
- •Hematopoietic:
- •WBC at least 2,500/mm^3
- •Absolute neutrophil count at least 1,500/mm^3
- •Platelet count at least 100,000/mm^3
- •Hemoglobin at least 10 g/dL
- •Hematocrit at least 30%
- •Bilirubin no greater than upper limit of normal (ULN)
- •AST no greater than 1.25 times ULN
- •Hepatitis B surface antigen negative
- •Hepatitis C antibody nonreactive
- •Creatinine less than 1.25 times ULN
- •Immunologic:
- •Antinuclear antibody (ANA) negative OR
- •If ANA positive, must be:
- •Antithyroglobulin antibody negative
- •Rheumatoid factor negative
- •Anti-LKM antibody negative
- •Anti-phospholipid antibody negative
- •Anti-islet cell antibody negative
- •Anti-neutrophil cytoplasmic antibody negative
- •HIV negative
- •No autoimmune disease (e.g., uveitis or autoimmune inflammatory eye disease)
- •No active infection
- •No hypersensitivity to tyrosinase:368-376, gp100:209-217, MART-1:26-35, or Montanide ISA-51
- •No other malignancy within the past 5 years except adequately treated basal cell or squamous cell skin cancer, superficial bladder cancer, or carcinoma in situ of the cervix
- •No underlying medical condition that would preclude study
- •Not pregnant or nursing
- •Negative pregnancy test
- •Fertile patients must use effective contraception
- •PRIOR CONCURRENT THERAPY:
- •Biologic therapy:
- •See Disease Characteristics
- •No prior anti-cytotoxic T-lymphocyte-associated antigen-4 monoclonal antibody
- •No prior tyrosinase, gp100, or MART-1 peptide
- •No prior antitumor vaccination
- •No prior interleukin-2
- •At least 4 weeks since prior immunotherapy for melanoma
- •Chemotherapy:
- 另有 11 项未显示
排除标准
- 未提供