BIOMarker PILOT study to identify the Acute risk of a Coronary Syndrome (BIOMArCS PILOT)” and Hartinfarct-biomarker onderzoek (deel I)” .
Recruiting
- Conditions
- 1. Acute coronary syndromes<br /> 2. unstable angina pectoris<br /> 3. non ST-elevation myocardial infarction<br /> 4. ST-elevation myocardial infarction<br />(Nederlands: acuut coronaire syndromen, instabiele angina pectoris, non ST-elevatie hartinfarct, ST-elevatie hartinfarct, coronaire vaatziekten, biomarkers, atherosclerose).<br /> 5. coronary artery disease<br /> 6. biomarkers<br /> 7. atherosclerosis
- Registration Number
- NL-OMON29278
- Lead Sponsor
- Initiator / Lead Principal Investigator:H. Boersma, PhD, MSc. Erasmus Medical Center (EMC), Department of Cardiology, section Clinical Epidemiology. Postaddress: P.O. Box 2040, 3000 CA RotterdamAddress: 's-Gravendijkwal 230 Postalcode: 3015 CE City: RotterdamCountry: Netherlands Telephone: +31 10 4632307 Fax: +31 10 4089484E-mail: h.boersma@erasmusmc.nl
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 100
Inclusion Criteria
Patients to be included must meet the following criteria:
1. Men or women with a minimum age of 40 years who are admitted with the clinical diagnosis of an acute coronary syndrome. The diagnosis should be based on the combination of typical ischemic chest complaints and objective evidence of myocardial ischemia or myocardial necrosis as demonstrated by the electrocardiogram (ECG) or elevated cardiac markers, as follows:
Exclusion Criteria
Patients will be excluded from this study for any of the following reasons:
1. Myocardial ischemia precipitated by a condition other than atherosclerotic coronary artery disease (e.g. arrhythmia, severe anemia, hypoxia, thyrotoxicosis, cocaine, severe valvular disease, hypotension).
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The general aim of this trial is to identify appropriate biochemical markers that are associated with plaque instability and the development of acute coronary syndromes and to furthermore prospectively study and describe the variability and evolution of biomarker patterns in 100 patients during the first months after admission for an acute coronary syndrome.
- Secondary Outcome Measures
Name Time Method A subsequent aim of this trial is to create an infrastructure for repeated biomarker sampling that can easily be expanded to perform further projects involving biomarkers in acute coronary syndromes.