Anemia of Inflammation: Investigation on Impaired Iron Regulation in Acutely Ill Patients and Their Clinical Outcome
试验速览
- 阶段
- 不适用
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- impact of acute inflammatory state on hemoglobin levels
研究概览
简要总结
Anemia of inflammation (AI), a normochromic, normocytic anemia, associated with abnormal iron utilization, erythropoietin hyporesponsiveness, and decreased red blood cells (RBC) survival is a very common problem in hospitalized patients for acute inflammatory diseases and develops within few days from the onset of illness. Deleterious effects of anemia include increased risk of cardiac related morbidity and mortality in critically ill and older patients.
Anemia is mediated by hepcidin, the 25-amino acid polypeptide hormone that is central to iron trafficking.
Several studies have been performed on pathophysiology of AI in patients affected by chronic diseases but few explore iron metabolism in humans with acute inflammation.
The aim is to develop effective new strategies to detect and manage AI in the setting of acutely ill patients, based on the understanding of iron balance underlying this disorder.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- 未提供
排除标准
- •any haematological diseases
- •cancer under chemotherapy
- •AIDS (or HIV+)
- •liver cirrhosis
- •genetic hemochromatosis
- •immunosuppressive therapy
- •blood transfusion in the past 30-days
结局指标
主要结局
impact of acute inflammatory state on hemoglobin levels
时间窗: 6 days - 8 days
Hemoglobin levels, Blood Red Cells markers, C-RP and other routinary inflammatory markers on day 1 and day 6 (or 8), IL-1, IL-4, IL-6, IL-10, alpha-TNF, gamma-IFN, GDF-15, erythropoietin and hepcidin on day 1 and on day 6 (or 8)
次要结局
- impact of acute inflammatory cytokines on hepcidin-driven iron balance and monocytes role in anemia of acute inflammation(6 days - 8 days)