ISRCTN10186987招募中不适用
Effect of PRAvastatin in Pregnancies complicated by Ischemical Placental Disease: prospective observational study
适应症
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 70
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational
入排标准
- 性别
- Female
入选标准
- •1. Pregnant women with PE and/or IUGR diagnosed between 20 and 34 gestational weeks, irrespective of maternal age.
- •2. PE will be defined as a newly onset hypertension in pregnancy (SAP > 140 mm ?g or DAP > 90 mm ?g) and significant proteinuria (>300mg/24h)
- •3. IUGR is defined as an estimated fetal weight <10th percentile with associated findings of placental insufficiency as a high resistance in the uterine arteries or in the umbilical artery (Pulsatility Index>95th percentile) or reduced amniotic fluid (maximum vertical pocket < 2 cm)
- •The control group:
- •1. Historical sample of women that were hospitalised during the 5 previous years in the Maternal fetal medicine unit of the 3rd Obstetrics and Gynecology University clinic
- •2. Pravastatin not used in treating the disease
- •3. Controlled for maternal age and the estimated fetal weight percentile.
排除标准
- •1. Pre-existing hypertension
- •3. Liver or connective tissue disease
- •4. Uterine malformations
- •5. Twin pregnancy
- •6. Fetal chromosomal abnormalities
研究者
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