End-range Mobilization Effecting Pressure Pain Threshold in Knee Osteoarthritis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 40
- 试验地点
- 2
- 主要终点
- PPT of the knee
研究概览
简要总结
Pain in knee osteoarthritis (OA) represents increased pain intensity due to peripheral and central sensitivity. Pressure pain threshold (PPT) is a widely applied (used) method for measuring the magnitude of peripheral and central sensitivity in knee OA. Among several manual therapy techniques increasing PPT in knee OA, the effect of end-range mobilization has not been evaluated so far. The aim of this study was to investigate the immediate effect of end-range mobilization compared to placebo on increase of PPT and some function-related measures.
详细描述
Knee osteoarthritis (OA) is the most common form of arthritis contributing to a major cause of disability worldwide. Although many mechanisms may contribute to knee pain severity, the patient-reported hyperalgesia can be attributed to peripheral and central sensitivity in knee OA. Pressure pain threshold (PPT) measurement is a simple and commonly applied method for measuring somatosensory function in musculoskeletal disorders, just as in knee OA. Many trials have shown a lower PPT value in knee OA underlining the presence of peripheral and central sensitivity compared to healthy controls.
Manual therapy techniques, as a preferred treatment option, may not only alleviate pain, but also increase pain tolerance to locally applied mechanical pressure. Positive results of different manual therapy techniques on increase of PPT has been reported in knee OA. End-range manual therapy is an option for the decrease of sensitivity in knee OA; however, the effect of end-range mobilization has not been evaluated so far in knee OA.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 60 Years 至 80 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •the clinical classification criteria of knee OA according to the American College of Rheumatology
- •Categorization of patients as End Of Range Problem based on Maitland manual therapy
- •female patients aged between 60 and 80 years
- •uni/bilateral moderate-to-severe symptomatic tibiofemoral knee osteoarthritis with radiographic evidence of Kellgren-Lawrence scale 2 or 3
- •pain during weight-bearing activities at least within 6 months
- •at least 90° knee flexion
- •sufficient mental status.
排除标准
- •acute inflammation of the knee
- •total knee replacement in the opposite side
- •severe degenerative lumbar spine disease (e.g. spondylolisthesis)
- •systemic inflammatory arthritic or neurological condition
- •physiotherapy/balneotherapy attendance or manual therapy within 3 months
- •intraarticular injections in the prior 12 months
- •use of walking aids
- •contraindication for manual therapy
- •complex regional pain syndrome
- •cognitive impairment
结局指标
主要结局
PPT of the knee
时间窗: 30 minutes
pressure pain threshold at the knee
次要结局
- Pain intensity during Timed Up and Go test(30 minutes)
- Passive tension of the knee(30 minutes)
- PPT of the m. Extensor Carpi Radialis Longus (ECRL)(30 minutes)
- General Pain Intensity(30 minutes)
- Timed Up and Go test(30 minutes)