High Intensity Resistance Training and Possible Sarcopenia

Not Applicable

Completed

• Conditions: Sarcopenia
• Interventions: Other: High Intensity Resistance Training

• Registration Number: NCT05985616
• Lead Sponsor: Riphah International University

Brief Summary

Studies conducted so far added the dietary supplements along with resistance training as an intervention, we could not determine whether the observed effects of the intervention were due to the training program and/or dietary supplements.

Detailed Description

This study will investigate the effects of high intensity resistance training solely in the possible sarcopenia cases which has not done before, to author's knowledge. Furthermore this study will help clinicians to individualize and optimize the therapy for specific patient subgroups, improve the potential of this therapy to improve human function and well being, facilitate timely interventions in community healthcare and prevention settings, which will contribute to higher awareness of sarcopenia prevention and interventions in diverse health care settings.

Study Timeline

• Study First Submitted: 2023-08-03
• Study First Submitted QC: 2023-08-03
• Study First Posted: 2023-08-14
• Study Start: 2023-08-15
• Primary Completion: 2023-12-31
• Study Completion: 2024-01-19
• Status Verified: 2024-03
• Last Update Submitted: 2024-03-04
• Last Update Posted: 2024-03-05

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 32

Inclusion Criteria

• Both male and female
• Age more than 60 years
• Possible sarcopenia cases as defined by Asian Working Group for Sarcopenia (Handgrip strength: Male less than 26kg and Female less than 18kg, 5 time chair stand test more than/equals to 12 seconds)

Exclusion Criteria

• Orthopedic surgery in last one year
• Neurological disorders like stroke etc
• History of recent fractures
• Metabolic disorders like DM etc
• Actively involved in exercise programs
• Cognitive impairment that could confound the assessment
• Wheelchair or bed bound individuals

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Group A	High Intensity Resistance Training	High intensity (80-85% of 1RM) will be administered at alternative days for 16 weeks. The exercise will have three phases; Phase I consists of 2-3 sets of 8-15 repetitions, Phase II will follow the single set approach and Phase III will have the Superset approach. The following activities will be incorporated via resistance training: latissimus front pulleys, rowing, back extension, inverse fly, bench press, shoulder press, lateral raises, butterfly with extended arms, crunches, leg presses, leg extension and curls, leg adduction, abduction.

Primary Outcome Measures

Name	Time	Method
Hand Dynamometer	16 weeks	it used to measure the hand grip strength. the test-retest reliability is 0.91 and 0.95 with excellent reliability. The assessment will be made at baseline, week 8 and 16
Short performance physical battery	16 Week	an objective assessment tool for evaluating lower extremity functioning in older persons. the test-retest reliability is 0.87. It was used to measure at baseline, week 8 and 16

Secondary Outcome Measures

Name	Time	Method
FRAIL	16 week	The questionnaire aims at fatigue, resistance, ambulation, illness and loss of weight. It is a self reported questionnaire. The sensitivity of FRAIL is 85.8% and a specificity of 80.6%.; The test will be measured at baseline, week 8 and 16

Trial Locations

Locations (1)

Abbas Institute of Medical Sciences; 🇵🇰 Muzaffarābād, Azad Kashmir, Pakistan