ISRCTN63231313
Active, Not Recruiting
Phase 3
Remote Ischaemic Conditioning After Stroke Trial (ReCAST- 3)
niversity of Nottingham0 sites1,300 target enrollmentApril 20, 2020
Overview
- Phase
- Phase 3
- Intervention
- Not specified
- Conditions
- Adults with acute ischaemic stroke presenting in Emergency Departments and Stroke Units in the UK
- Sponsor
- niversity of Nottingham
- Enrollment
- 1300
- Status
- Active, Not Recruiting
- Last Updated
- 2 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Current participant inclusion criteria as of 20/12/2023:
- •1\. Hyperacute ischaemic stroke
- •2\. \< 24h post stroke onset
- •3\. Primary intracerebral haemorrhage ruled out on baseline clinical neuroimaging
- •4\. NIHSS score of 5\-25 at randomisation
- •5\. Aged 18 years or above
- •Previous participant inclusion criteria as of 29/04/2020 to 20/12/2023:
- •1\. Hyperacute ischaemic stroke
- •2\. \< 6 h post stroke onset
- •3\. Primary intracerebral haemorrhage ruled out on baseline clinical neuroimaging
Exclusion Criteria
- •Current participant exclusion criteria as of 20/12/2023:
- •1\. Pre\-morbid dependency (modified Rankin Scale, mRS\>3\)
- •2\. Systolic BP \=80 mmHg
- •3\. Spontaneous intracerebral haemorrhage
- •4\. Haemorrhagic transformation of infarction PH2 if known before randomisation (not excluded or withdrawn if occurs after randomisation)
- •5\. Dementia \- if the patient had a pre\-existing diagnosis
- •6\. Coma (GCS \<8\)
- •7\. Malignancy and significant co\-morbidity (life expectancy \<6 months)
- •8\. BM \<3\.0 mmol/L
- •9\. Seizure on presentation unless brain imaging identifies evidence of significant brain ischaemia
Outcomes
Primary Outcomes
Not specified
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