Effects of Interactive Stepping Exercise on Memory in Adults With Amnestic Mild Cognitive Impairment
试验速览
- 阶段
- 不适用
- 入组人数
- 30
- 主要终点
- Selective reminding test
研究概览
简要总结
This is a randomized controlled trail. A total of 28 individuals with aMCI will be randomly assigned to either the ISE group or control group. The ISE intervention conducts three times a week for 16 weeks. Outcomes are measured at baseline and after intervention. The primary outcomes are the Chinese version verbal learning test (CVVLT), selective reminding test (SRT), and logic memory test (Wechsler Memory Scale). The secondary outcomes are Montreal Cognitive Assessment (MoCA) for cognitive function, and trail making test Part A & B (TMT-A & B), Stroop test, and 25-item Executive Interview (C-EXIT 25) for executive function.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 50 Years 至 100 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age≥50 years
- •Complained of memory impairment
- •Chinese Version Verbal Learning Test 10-minute delays ≤ 6 words
- •MMSE score≥24 and CDR score=0.5
- •Activities of daily living are intact
- •DSM-IV criteria for the diagnosis of dementia is not met
排除标准
- •Any significant neurologic disease other than suspected incipient Alzheimer's disease
- •Psychotic features, contraindication of exercise... which could lead to difficulty complying with the protocol
研究组 & 干预措施
Interactive stepping exercise group
干预措施: Interactive stepping exercise (Other)
Home exercise group
干预措施: Home exercise (Other)
结局指标
主要结局
Selective reminding test
时间窗: Change from baseline at 12 week
Chinese version verbal learning test
时间窗: Change from baseline at 12 week
Logic memory test
时间窗: Change from baseline at 12 week
Wechsler Memory Scale-III
时间窗: Change from baseline at 12 week
次要结局
- Montreal Cognitive Assessment(Change from baseline at 12 week)
- Stroop test(Change from baseline at 12 week)
- Trail making test(Change from baseline at 12 week)
- Executive Interview(Change from baseline at 12 week)
研究者
Yea-Ru Yang
Professor
National Yang Ming Chiao Tung University