Environmental tobacco smoke as a risk factor for the development of oral squamous cell carcinoma – a multicentric case-control-study (PROSCC)

• Conditions: C02; C03; C04; C05; C06; Malignant neoplasm of other and unspecified parts of tongue; Malignant neoplasm of gum; Malignant neoplasm of floor of mouth; Malignant neoplasm of palate; Malignant neoplasm of other and unspecified parts of mouth

• Registration Number: DRKS00034483
• Lead Sponsor: niversitätsmedizin Göttingen

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2024-06-17
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Pending
• Sex: All
• Target Recruitment: 320

Inclusion Criteria

Case group:
Biopsy-proven oral squamous cell carcinoma
Age > 18 years
existing capacity to consent

Control group:
No diagnosed oral squamous cell carcinoma
Age > 18 years
existing capacity to consent
not a family member 1° of a case

Exclusion Criteria

Case group:
Oro-, naso- hypopharyngeal carcinoma, lip carcinoma
History of other malignant disease
Age < 18 years
no existing capacity to consent
Immunosuppression

Control group:
Age < 18 years
no existing capacity to consent
History of malignant disease
Immunosuppression
Family member 1° of a case

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
ETS Score (ETS = environmental tobacco smoke), OR (Odds ratio)

Secondary Outcome Measures

Name	Time	Method
corresponding clinical and histopathological characteristics