Collagen Matrix vs. Connective Tissue Graft for peri-implant soft tissue augmentatio

Not Applicable

• Conditions: Tissue Transplantation; C07.465.550

• Registration Number: RBR-38gcwz9
• Lead Sponsor: FAESA-Centro Universitário Espíritosantense

Brief Summary

It has been showed that thick peri-implant mucosa optimizes health and longevity. Connective tissue grafts are considered the “gold standard”, however, soft tissue substitutes are an alternative to decrease patient morbidity. The aim of this randomized controlled split-mouth clinical trial is to assess the soft tissue thickness after implant reopening and grafting using a connective tissue graft or collagen matrix in the posterior mandible. Eight patients who had submerged implants installed bilaterally and reduced soft tissue thickness were randomly assigned to receive a connective tissue graft or collagen matrix at each side. A reopening procedure was performed and implants received a personalized healing abutment and a soft tissue graft. Data was collected from the patients at 3 different time points: baseline, 3, and 18 months. Linear measurements were made at alveolar ridge crest, 1, 2, and 3 mm below. Time of surgery and patient related outcomes were assessed. Intragroup assessments showed an increase in soft tissue thickness at all time points compared to baseline on both groups. Intergroup comparison showed a significant difference favoring connective tissue graft where there was a greater gain of soft tissue thickness and stability throughout time. The average gain of soft tissue thickness from baseline to 18 months on connective tissue graft and collagen matrix groups were 2.08±0.98 mm and 0.82±0.47, respectively. The type of graft did not influence postoperative morbidity while surgery time was higher in the connective tissue graft group. Sites that received a connective tissue graft presented higher soft tissue thickness gain. Soft tissue thickness was stable over time in group connective tissue graft and showed a decrease in group collagen matrix after 18 months

Detailed Description

Not available

Study Timeline

• Study Completion: 2022-05-15
• Study Start: 2024-06-24
• Last Update Posted: 22 July 2024

Recruitment & Eligibility

• Status: Data analysis completed
• Sex: Not specified
• Target Recruitment: Not specified

Inclusion Criteria

Good oral hygiene with visible plaque index less than 20%; age higher or equal to 18 years; both genders; sufficient tissue availability to harvest an autogenous soft tissue graft from the palate with 12 mm width, 8 mm height, and 2 mm of thickness; soft tissue at the implant site with a thickness inferior to 2 mm; an implant installed for at least 3 months in both sides of the posterior mandible; need for reopening procedure in the implants

Exclusion Criteria

Systemic alterations; presence of inflammation or infection involving the regions where the surgical procedures were performed; bone pathology in the implant site; smoking; excessive use of alcohol; drug addiction; diabetes; pregnancy or desire to become pregnant in the next year; history of radiotherapy treatment in the head and neck region, and people who take medications that may interfere with bone remodeling or who have pathologies that affect bone metabolism

Study & Design

• Study Type: Intervention
• Study Design: Not specified