Risk assessment for the developing of a postoperative delirium in cardiac surgical patients on the basis of serum cholinesterase activity

• Conditions: F05.8; Other delirium

• Registration Number: DRKS00012630
• Lead Sponsor: Klinik für Anästhesiologie, Intensiv-, Palliativ- und Schmerzmedizin; Berufsgenossenschaftliches Universitätsklinikum Bergmannsheil GmbH

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Completion: 2016-04-03
• Study Start: 2017-07-14
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 115

Inclusion Criteria

Adults, consenting patients > 18 years;
Cardiac surgery with or without a cardio-pulmonary bypass receiving an aortocoronary bypass or aortic valve operation;
ASA I - IV

Exclusion Criteria

Absence of consent;
Dementia;
Failed mini mental test (MMST);
Patients with Parkinson's disease;
Patients with Alzheimer's disease

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Correlation between the pre-/perioperative serum acetyl or butyrylcholinesterase concentration and the neuropsychological outcome of the patients.<br><br>Neuropsychological outcome, ie the occurrence of a delirium, is measured on 1, 2, 3, and 5 postoperative days, using the specific delirium questionnaires Nu-DESC and ICDSC. The acetyl and butyrylcholinesterase concentrations are measured in parallel for this purpose.

Secondary Outcome Measures

Name	Time	Method
Modification of serum acetyl- or butyrylcholinesterase concentrations in patients undergoing cardio-vascular surgery; preoperatively, a capillary withdrawal of blood from the fingertip or the ear lobe for the determination of the acetyl- and butyrylcholinesterase is performed, as well as immediately postoperatively on the operating day and in the further course on the first, second, third and fifth postoperative days.<br><br>Influence of the cardio-pulmonary bypass on the course of acetylcholinesterase and butyrylcholinesterase activity and neuropsychological outcome of the patients.<br><br>Influence of various surgical procedures (aortocoronary bypass surgery and aortic valve replacement) on cholinesterase activity.<br><br>