The effect of pre-emptive intravenous ondansetron on patients presented to elective C.S under combined spinal-epidural anesthesia

Not Applicable

• Conditions: Circulatory System; Anaesthesia

• Registration Number: PACTR201809811205627
• Lead Sponsor: tanta university

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2018-09-01
• Last Update Posted: 29 May 2023

Recruitment & Eligibility

• Status: Pending
• Sex: Female
• Target Recruitment: 60

Inclusion Criteria

60 Patients
presented for elective cesarean sections
American Society of Anesthesiologists (ASA) patient status classification II
ages 21-40 years

Exclusion Criteria

1. Age younger than 21 or older than 40 years
2. Major cardiovascular diseases
3. Preexisting hypertension or gestational hypertension, preeclampsia
4. Body mass index greater than 35 kg/m2.
5. Emesis gravidarum
6. Contraindication to neuraxial anesthesia (patient refusal, unstable hemodynamic, and coagulation abnormalities)
7. Any study drugs allergy.
8. emergent cesarean sections, multiple parities (twins/triplets)
9. > 1,000 ml blood loss,

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The incidence of hypotension will be collected at pre-defined time points: baseline measurement while supine (T0), in the sitting position (T1), immediately after injection of spinal anesthesia (T2), 5 and 10 min after spinal anesthesia while supine (T3, T4), at skin incision (T5), 3 min after skin incision (T6), at newborn delivery (T7), 3 min after delivery (T8), 10 min after delivery (T9) and at the end of surgery (T10).

Secondary Outcome Measures

Name	Time	Method
changes in the heart rate will be collected at pre-defined time points: baseline measurement while supine (T0), in the sitting position (T1), immediately after injection of spinal anesthesia (T2), 5 and 10 min after spinal anesthesia while supine (T3, T4), at skin incision (T5), 3 min after skin incision (T6), at newborn delivery (T7), 3 min after delivery (T8), 10 min after delivery (T9) and at the end of surgery (T10). and the effect of the APGAR score.