DRKS00040643招募中不适用
Improving Autobiographical Memory via Visual Imagery through tDCS in Aphantasia - ENHANCE
适应症
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 80
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 95 Years（—）
- 性别
- All
入选标准
- •Group-specific inclusion criterion – Aphantasia group:
- •A VVIQ score (Vividness of Visual Imagery Questionnaire, Marks 1973) below 32 out of a possible 80 points indicates the presence of aphantasia, based on general research findings (e.g., Dawes et al., 2020; Monzel et al., 2024), and will therefore be treated as an inclusion criterion for the aphantasia group in this study. The healthy control group is required to achieve a VVIQ score above
- •For individuals with hippocampal lesions, the VVIQ score will be recorded, but this is not relevant for inclusion or exclusion.
- •Group-specific inclusion criterion – Hippocampal Lesions group:
- •20 individuals with hippocampal lesions, such as mild cognitive impairment due to Alzheimer's disease, a history of limbic encephalitis, a history of ischemia/hypoxemia, or hippocampal tumors. These are confirmed conditions affecting the hippocampus, which may include both functional impairment and morphological changes of the hippocampus. All patients with hippocampal lesions must be capable of providing informed consent. If there is any indication that this capacity is not present, the individual will not be enrolled in the study.
排除标准
- •Group-specific exclusion criteria – Aphantasia and Control groups:
- •Neurological, psychiatric, or serious internal medical conditions.
- •MRI exclusion criteria:
- •The following exclusion criteria apply to the MRI examination: cardiac or cranial surgeries, cardiac pacemakers, medication pumps (e.g., insulin pumps), hearing aids, removable dental prosthetics, metal parts in or on the body (e.g., acupuncture needles, artificial joints, vascular prostheses, metal fragments, metal clips, implanted electrodes, permanent makeup), and claustrophobia. All participants interested in taking part in the study will be read a questionnaire containing the relevant inclusion and exclusion criteria. Based on the questionnaire, it can be determined whether interested participants qualify for the study. The exclusion criteria will be reviewed again by a study physician at the DZNE prior to the MRI examination. If sufficient documentation attesting to MRI suitability is provided — such as an implant passport, surgical report, etc. — MRI participation may be approved in collaboration with the DZNE's MRI safety officer. Participants sign and confirm that they meet the above-mentioned criteria in order to proceed with the experiments. The presence of neurological, psychiatric, or serious internal medical conditions is also treated as an exclusion criterion.
- •tDCS stimulation exclusion criteria:
- •In order to participate in transcranial direct current stimulation (tDCS), the following additional exclusion criteria apply:
- •Skull openings or following cranial trepanation
- •Not to be used in combination with a defibrillator or high-frequency surgery
- •Brain stimulator
- •Implanted intracranial metals (e.g., plates, screws, fragments, ventriculoperitoneal shunt, endoprostheses, etc.)
- •Skin damage (injuries, scars, psoriasis on the scalp)
- •Traumatic brain injury involving loss of consciousness, brain surgery, or brain tumors
- •Pregnancy
- •If contact with the scalp cannot be established
研究者
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