Cognitive Ability Training in Seniors

Not Applicable

Completed

• Conditions: Mild Cognitive Impairment
• Interventions: Device: Sham tDCS; Device: Verum tDCS

• Registration Number: NCT02587338
• Lead Sponsor: Wuerzburg University Hospital

Brief Summary

This study investigates the beneficial effects of prefrontal brain stimulation (with transcranial direct current stimulation \[tDCS\]) during working memory training in seniors with subjective memory impairments.The placebo-controlled double blinded study includes 50 elderly probands which were randomized into verum or sham tDCS.

Detailed Description

Not available

Study Timeline

• Study Start: 2015-05
• Study First Submitted: 2015-06-16
• Study First Submitted QC: 2015-10-26
• Study First Posted: 2015-10-27
• Primary Completion: 2016-10
• Study Completion: 2016-12
• Results First Submitted: 2022-08-31
• Status Verified: 2024-03
• Results First Submitted QC: 2024-03-11
• Last Update Submitted: 2024-03-11
• Results First Posted: 2024-03-12
• Last Update Posted: 2024-03-12

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 38

Inclusion Criteria

• native german speaker
• between 60-70 years old
• subjective memory impairment

Exclusion Criteria

• psychiatric, neurological diseases
• uncorrected hearing or vision deficits
• actual psychopharmaco intake
• metal parts in the head
• medical electronical implants

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Sham tDCS	Sham tDCS	sham stimulation, same electrode positions
Verum tDCS	Verum tDCS	Left frontal anodal stimulation, supraorbital right cathodal stimulation

Primary Outcome Measures

Name	Time	Method
Neuropsychological Performance in Neuropsychological Test: Verbal Learning Memory Test (VLMT)	4 weeks	The Investigators are measuring cognitive performance for different executive functions, here the score (percentile of the norm values) of the test verbal learning memory test (VLMT), parameter immediate recall post treatment is reported. Rage from 0 to 100 %. Higher values indicate higher performance.

Secondary Outcome Measures

Name	Time	Method
Brain Activation Measured With Near-infrared Spectroscopy (NIRS) During the Semantic Condition of the Verbal Fluency Task (VFT)	4 weeks	NIRS is a brain imaging method, with the parameters of oxy (OxyHB) and deoxy (deoxyHB) hemoglobin. Activation is reflected by increase of OxyHB and decrease DeoxyHB. Differences from pre- to post-measurement for OxyHB are reported in a region of interest analysis of the dorsolateral prefrontal cortex.

Trial Locations

Locations (1)

University hospital; 🇩🇪 Wuerzburg, Germany