Greater Houston Area Pediatric Bipolar Registry
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 1,000
- 试验地点
- 1
- 主要终点
- Positive Identification of Bipolar Disorder as Assessed by Mini-International Neuropsychiatric Interview for Children and Adolescents (MINI Kid 7.2) (child)
研究概览
简要总结
The purpose of this study is to perform a comprehensive research assessment of children and adolescents who meet The Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-V) criteria for Bipolar Disorder (BD) , offspring of a parent with BD, and healthy controls (HC), to obtain blood samples and saliva samples from each subject to allow the evaluation for BD biomarkers and genetic information, to notify participants about future research studies they may qualify for , to recommend follow-up with an outpatient provider if needed and to use magnetic resonance imaging (MRI) (structural MRI and diffusion tensor imaging) to investigate brain structures and relevant pathways associated with mood and behavioral regulation, conversion from softer forms of the BD spectrum (BD-NOS) to harder forms (BD-I and BD-II) and possible early identification.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 6 Years 至 17 Years（Child）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •for bipolar patients or offspring of bipolar parents:
- •Any current mood state (in the case of bipolar subjects)
- •For bipolar patients: DSM-V criteria for BD type I, BD type II, or BD NOS, as per the administration of the Mini International Neuropsychiatric Interview for Children and Adolescents (MINI-KID)
- •For the offspring of bipolar parents: at least one parent meeting DSM-V criteria for BD type I or BD type II, or BD NOS as per the administration of the MINI Adult
排除标准
- •for bipolar patients or offspring of bipolar parents:
- •Autism Spectrum Disorder (ASD)
- •Developmental Intellectual Disorder
- •Severe Neurological Disorder that affects cognitive status (e.g., epilepsy, traumatic brain injury, tubular sclerosis)
- •Schizophrenia
- •Uncontrolled or severe medical problem per investigator judgment
- •For the offspring: parents with a history of any brain diseases, including seizures, stroke, meningitis, encephalitis, dementia, and other degenerative brain diseases; parents with a history of intellectual disability
- •Exclusion Criteria for healthy control subjects:
- •Any Psychiatric Diagnosis
- •Any family history of Bipolar Disorder, Psychotic Disorder, Schizophrenia, or Schizoaffective disorder in a first-degree relative
- •Any family history of a neurological condition in a first-degree relative.
- •Mental Retardation/Intellectual Disability
- •Severe Neurological Disorder that affects cognitive status (e.g., epilepsy, traumatic brain injury, tubular sclerosis)
- •Schizophrenia
- •Uncontrolled or severe medical problem per investigator judgement
- •Exclusion criteria for annual visits:
- •Autism Spectrum Disorders (ASD)
- •Intellectual Developmental Disorder
- •Severe Neurological Disorder that affects cognitive status (e.g., epilepsy, traumatic brain injury, tubular sclerosis)
- •Schizophrenia
- •Uncontrolled or severe medical problem per investigator judgement
研究组 & 干预措施
Bipolar Patients
Offspring of Bipolar Parents
Healthy Control Subjects
结局指标
主要结局
Positive Identification of Bipolar Disorder as Assessed by Mini-International Neuropsychiatric Interview for Children and Adolescents (MINI Kid 7.2) (child)
时间窗: baseline, annually until participant turns 25 years of age
次要结局
未报告次要终点
研究者
Jair Soares
Professor
The University of Texas Health Science Center, Houston