Intrarenal activation of renin-angiotensin system impairs circadian blood pressure rhythm.
Not Applicable
Recruiting
- Conditions
- Chronic kidney disease (CKD)
- Registration Number
- JPRN-UMIN000002591
- Lead Sponsor
- Department of Cardio-Renal Medicine and Hypertension, Nagoya City University Graduate School of Medical Sciences
- Brief Summary
data acquirement is not completed. Twenty patients has been enrolled.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 40
Inclusion Criteria
Not provided
Exclusion Criteria
Exclusion criteria are as follows; use of inhibitors of renin-angiotensin system or diuretics 1 month before enrollment; specific contraindication to a study drug; presence or possibility of pregnancy; HbA1c of 9.0 % or above; serious liver damage (GOT >100, or GPT >85); secondary hypertension; accelerated or malignant hypertension (progressive renal dysfunction with diastolic BP of >120-130 mmHg); serious congestive heart failure, coronary heart disease, arrhythmia, or systemic diseases; or any reason for ineligibility suggested by the attending doctor.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The primary purpose of this study is to investigate whether there is a positive relationship between the intrarenal activation of renin-angiotensin system (RAS), represented by Angiotensinogen (AGT) expression in the renal-biopsy specimens or urinary excretion of AGT, and night/day ratio of blood pressure, natriuresis or albuminuria, and whether the more intrarenal RAS is activated at baseline, the more the reduction in night/day ratio of blood pressure, natriuresis or albuminuria is.
- Secondary Outcome Measures
Name Time Method The secondary purpose of this study is to evaluate whether night/day ratio of urinary excretion rate of AGT shows positive relationship with night/day ratio of blood pressure, natriuresis or albuminuria, and negative one with creatinine clearance and to investigate, in case that the second biopsy is performed, whether the more AGT expression is reduced, the more night/day ratio of blood pressure, natriuresis or albuminuria is decreased. IHC for pro-renin and ACE2 expression is to be studied.