„Limited Options with Extended Resistance to antiretroviral therapy: A National Survey of Triple Class Resistance”
- Conditions
- B24Unspecified human immunodeficiency virus [HIV] disease
- Registration Number
- DRKS00012396
- Lead Sponsor
- ICH Study Center
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 243
Inclusion Criteria
Documented HIV-infection, age of at least 18 years, documented triple-class-resistance (NRTIs, NNRTIs, PIs or INSTIs), documented by at least one resistance test), written informed consent
Exclusion Criteria
No documented triple-class resistance, medical illness that does not allow safe blood draw, age under 18 years, cognitive impairment leading to inability to fill out the questionnaires and/or to give informed assent or consent.
Study & Design
- Study Type
- observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Concordance between current resistance analysis (evaluated by ultra deep sequencing from proviral DNA) and prior resistance pattern (historical test results)
- Secondary Outcome Measures
Name Time Method Current antiretroviral therapy, remaining options. Virological and immunological situation. Physical and mental health of the patients. Adherence and treatment satisfaction with current antiretroviral therapy (evaluated by questionnaires)