NCT01758887撤回不适用
Antipsychotic Discontinuation in High-risk Subjects
适应症
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 试验地点
- 1
- 主要终点
- Presynaptic dopamine synthesis in the striatum
研究概览
简要总结
- Would be there any difference in dopamine synthesis between remitted clinical high risk subjects for psychosis and healthy control?
- What would happen to dopamine synthesis after antipsychotic discontinuation in clinical high risk subjects for psychosis?
- What about the dopamine synthesis in recurred clinical high risk subjects for psychosis after the discontinuation?
详细描述
After the antipsychotic medication discontinuation, we are going to assess the changes of the biological markers
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 16 Years 至 40 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Diagnosed as a clinical High Risk
- •Treated with antipsychotic drugs
- •PSP1-5 (from SIPS criteria) <3 (severity index)for more than 6 months
- •Had not experienced a symptomatic relapse in the 6 months
排除标准
- •Significant abnormality in laboratory tests
- •History of head trauma
结局指标
主要结局
Presynaptic dopamine synthesis in the striatum
时间窗: baseline
measured with \[18F\]DOPA positron emission tomography
次要结局
未报告次要终点
研究者
Jun Soo Kwon
Professor
Seoul National University Hospital
研究点 (1)
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