Antipsychotic Discontinuation in High-risk Subjects
Withdrawn
- Conditions
- Schizophrenia
- Registration Number
- NCT01758887
- Lead Sponsor
- Seoul National University Hospital
- Brief Summary
* Would be there any difference in dopamine synthesis between remitted clinical high risk subjects for psychosis and healthy control?
* What would happen to dopamine synthesis after antipsychotic discontinuation in clinical high risk subjects for psychosis?
* What about the dopamine synthesis in recurred clinical high risk subjects for psychosis after the discontinuation?
- Detailed Description
After the antipsychotic medication discontinuation, we are going to assess the changes of the biological markers
Recruitment & Eligibility
- Status
- WITHDRAWN
- Sex
- All
- Target Recruitment
- Not specified
Inclusion Criteria
- Diagnosed as a clinical High Risk
- Treated with antipsychotic drugs
- PSP1-5 (from SIPS criteria) <3 (severity index)for more than 6 months
- Had not experienced a symptomatic relapse in the 6 months
Read More
Exclusion Criteria
- Significant abnormality in laboratory tests
- History of head trauma
Read More
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Presynaptic dopamine synthesis in the striatum baseline measured with \[18F\]DOPA positron emission tomography
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Seoul National University Hospital
🇰🇷Seoul, Korea, Republic of