Antioxidants vs.Ovarian Bio-stimulation Therapy to Rescue the Ovarian Reserve
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 78
- 试验地点
- 2
- 主要终点
- variation of hormones FSH and LH directly involved with ovarian reserve
研究概览
简要总结
Two group of patients were selected. Group 1 represents 46 patients that received ovarian-biostimulation monthly for three months. Group 2 represents 32 patients that received antioxidant therapy daily for 3 months. Results are noted and analysed.
Both groups represent patients with procedures already ongoing, and with diagnosed poor or depleted ovarian reserve.
The analysis has been made to compare the efficacy of both procedures.
详细描述
The bioestimulation group received a blood rich platelet therapy monthly for three months, with a technique developed by the laboratory. The second group of antioxidants received a combination of antioxidants monthly for three months. Both groups were compared to assess the results in terms of ovarian response (number of astral follicles, AMH levels, FSH, LH), and egg quality, embryo development, implantation rate, and successful pregnancy with healthy live birth.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 38 Years 至 46 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Age between 38 and 46 years
- •FSH> 12 mIU
- •Estradiol > 100 pg/ml
- •AMH < 0.8 ng/mL
排除标准
- •Pelvic inflammatory syndrome
- •vaginal pathologies
- •known history of hyperandrogenism
- •diagnosed platelet disorders as adhesion
- •aggregation
- •disorder of thromboxane synthesis.
结局指标
主要结局
variation of hormones FSH and LH directly involved with ovarian reserve
时间窗: 18 months
Both groups are compared after bio-stimulation and antioxidant therapy is performed to access any possible changes with FSH-LH post-treatment.
variation of AMH directly involved with ovarian reserve in both groups
时间窗: 18 months
Both groups are compared after bio-stimulation and antioxidant therapy is performed to access any possible changes with AMH values.
variation in recruitment of antral follicles in both groups
时间窗: 18 months
Both groups are compared after bio-stimulation and antioxidant therapy is performed to access any possible changes with the number of astral follicles available.
次要结局
- Number of good quality eggs obtained in both groups after IVF(18 months)
- Number and quality of fertilised eggs obtained in both groups after IVF(18 months)
研究者
Lucy Coleman
Scientific director
Fertiaguerrevere