ISRCTN13384956
Active, not recruiting
未知
Evaluating the clinical and cost-effectiveness of a conservative approach to oxygen therapy for invasively ventilated adults in intensive care
Intensive Care National Audit & Research Centre (ICNARC)0 sites16,500 target enrollmentDecember 8, 2020
Overview
- Phase
- 未知
- Intervention
- Not specified
- Conditions
- Invasive ventilation in intensive care
- Sponsor
- Intensive Care National Audit & Research Centre (ICNARC)
- Enrollment
- 16500
- Status
- Active, not recruiting
- Last Updated
- last year
Overview
Brief Summary
2024 Protocol article in https://pubmed.ncbi.nlm.nih.gov/38737312/ (added 08/07/2024)
Investigators
Eligibility Criteria
Inclusion Criteria
- •1\. Aged \=18 years
- •2\. Receiving invasive mechanical ventilation in the ICU following an unplanned ICU admission (i.e. not admitted after an elective procedure) OR invasive mechanical ventilation started in the ICU (i.e. the patient was intubated in the ICU)
- •3\. Receiving supplemental oxygen (fractional inspired concentration of oxygen (FiO2\) \>0\.21\) at the time of enrolment
Exclusion Criteria
- •1\. Previously randomised into UK\-ROX in the last 90 days
- •2\. The clinician considers that one study treatment arm is either indicated or contraindicated.
- •Removed 20/04/2021:
- •A data dictionary will contain relevant examples of conditions where clinicians may exclude patients (at their discretion) because conservative oxygen therapy is either indicated or contraindicated (e.g. chronic lung diseases, receiving hyperbaric oxygen, prior bleomycin exposure, carbon monoxide poisoning).
- •Added 22/02/2021:
- •3\. Currently receiving extracorporeal membrane oxygenation (ECMO)
Outcomes
Primary Outcomes
Not specified
Similar Trials
Active, not recruiting
Not Applicable
Investigating the effectiveness of inpatient mental health rehabilitation services in the NHS and independent sectorMental healthMental and Behavioural DisordersISRCTN17381762Camden and Islington NHS Foundation Trust500
Active, not recruiting
Not Applicable
sing text message reminders and culturally-tailored telephone calls to promote participation in bowel cancer screening (TOPPS)Bowel cancer screeningCancerISRCTN17245519niversity College London2,703
Active, not recruiting
Not Applicable
Should we replace the back of the knee cap all of the time or some of the time in patients having knee replacement surgery? A trial comparing patient outcomes and the cost to the NHS.ISRCTN33276681orth Bristol NHS Trust530
Completed
Not Applicable
Evaluation of intensive community care services for young people with psychiatric emergenciesISRCTN42999542King's College London252
Active, not recruiting
Not Applicable
Collaborative deprescribing intervention of Proton-Pump Inhibitors among community-dwelling older adults: The C-SENIoR trialOverprescribing of proton-pump inhibitorsNot ApplicableISRCTN49637686ational Association of Pharmacies222