Pain Perception, Headache Provocation and Multiomics of People Who Are Unable to Have Headache
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Pericranial Muscle Tenderness: Total Tenderness Scores
研究概览
简要总结
Headaches are extremely common illnesses with a combined lifetime prevalence of 90-99% in Europe. Despite this high prevalence, there are persons who have never, in their whole life, encountered a headache.
The aim of the study is to identify factors that protect against headache by studying pain perception, muscle tenderness and pain tolerance in people who never have had a headache (headache resistant) versus non-resistant controls.
The investigators hope to contribute with novelty to the current understanding of headache pathophysiology and development of more efficient treatment of headache.
The investigator examining:
Quantitative sensory testing (cold pain threshold and heat pain threshold), Muscle tenderness (total tenderness score) and cold pressor test (time in the water and pain rating). All tests are performed the same day, by one investigator who are blinded to the grouping of the participants.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 否
入选标准
- •Headache resistant and non-resistant male participants from the Danish Blood Donor Study.
- •Weight: 45 kg to 95 kg
排除标准
- •Daily consumption of any medication.
- •Consumption of any medication less than 12 hours prior to the study day.
- •Headache on the study day or 48 hours prior to the study day.
- •Amnestic or clinical signs of hypertension (systolic blood pressure >150 mmHg and/or diastolic blood pressure >100 mmHg) or hypotension (systolic blood pressure <90 mmHg and/or diastolic blood pressure <50 mmHg).
- •Any severe cardiovascular disease, including cerebrovascular illness.
- •Amnestic or clinical signs of current mental illness.
- •Amnestic or clinical signs of current substance or drug abuse.
- •Amnestic or clinical signs of any illness the responsible doctor considers relevant for participation in the study.
结局指标
主要结局
Pericranial Muscle Tenderness: Total Tenderness Scores
时间窗: 3 hours
Difference in Total Tenderness Score between cases and controls. 8 pericranial muscles are palpated by the investigator and the tenderness is rated by the participant on a scale of 0-3 where 0 is no tenderness and 3 is severe tenderness.
Quantitative Sensory Test: Heat Pain Threshold
时间窗: 3 hours.
Difference in Heat Pain Threshold (celcius) between cases and controls.
Quantitative Sensory Test: Cold Pain Threshold
时间窗: 3 hours
Difference in Cold Pain Threshold (celcius) between cases and controls.
次要结局
- Cold Pressor Test: Pain Tolerance(3 hours)
- Cold Pressor Test: Pain Rating(3 hours)
研究者
Isa Amalie Olofsson
Medical Doctor, PhD student
Danish Headache Center