Research on the Role of the Amino Acid Transporter SLC1A5 in the Development of Esophageal Cancer
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 100
- 试验地点
- 2
- 主要终点
- optical density (ODs) of each slice by immunohistochemistry assay
研究概览
简要总结
To explore the significance of Solute Carrier Family 1 Member 5 (SLC1A5) in the occurrence of esophageal cancer, by comparing the expression of SLC1A5 between esophageal cancer tissues and adjacent tissues.
详细描述
This will be an observational study. The investigators will aim to enroll 100 male and female adult patients (aged 18 years and over) of all ethnicities/races, who have been referred to the Fourth Affiliated Hospital of Guangxi Medical University for esophageal cancer.
The investigators will be using a standardized data collection form. This is an observational study in which standard of care will be practiced and the patients are not placed at additional risk from participating in this study. However, as the investigators are collecting data prospectively, all participants will sign consent. An attempt will be made to see if there is a correlation between the expression of SLC1A5 with esophageal cancer.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with histologically proven esophageal cancer;
- •Age ≥18 years;
- •All patients must sign consent forms voluntarily;
排除标准
- •Inability to obtain histologic proof of malignancy.
- •Age <18 years;
结局指标
主要结局
optical density (ODs) of each slice by immunohistochemistry assay
时间窗: within one year (plus or minus 1 month) after surgery
For immunohistochemistry assay： Briefly, the samples will be cut into slices, which will be stained with standard steps. Finally, three high power fields will be randomly selected from each slice and the average optical density (OD) will be measured in each field.
次要结局
- SLC1A5 expression detected by WesternBlot(within one year (plus or minus 1 month) after surgery)