BE Intervention for Naloxone Uptake

Not Applicable

Completed

• Conditions: Harm Reduction
• Interventions: Behavioral: Text message nudges; Behavioral: Commitment contract

• Registration Number: NCT06064981
• Lead Sponsor: University of Pennsylvania

Brief Summary

The overall objective of this study is to use behavioral economics interventions to increase naloxone acquisition and carrying among participants who attend an opioid overdose reversal training.

Detailed Description

This study aims to use behavioral economics interventions to increase naloxone acquisition and carrying among participants who attend opioid overdose reversal training. The study consists of two distinct randomized controlled trials (Aim 2 and Aim 3) and has three primary objectives:

Aim 1: To diagnose behavioral bottlenecks to naloxone acquisition and carrying. This aim involves analyzing data from naloxone training sessions to identify barriers to acquiring and carrying naloxone. These barriers will be mapped to cognitive biases, such as optimism bias and overconfidence, and will inform the behavioral interventions in Aims 2 and 3.

Aim 2: To test the impact of a behavioral economics intervention on naloxone acquisition. This aim involves a randomized controlled trial with 60 participants. The intervention group will receive commitment pledges, acquisition plans, and tailored text message nudges to increase naloxone acquisition within one week of training. The control group will receive standard training. The primary endpoint is the time it takes for participants to acquire naloxone post-training.

Aim 3: To test the impact of a text nudge intervention on naloxone carrying. This aim also involves a randomized controlled trial, where all participants receive naloxone at the training. The intervention group will receive tailored text message nudges to encourage consistent naloxone carrying. The control group (n=30) will not receive these nudges. The primary endpoint is the consistency of naloxone carrying post-training.

Study Timeline

• Study Start: 2019-02-01
• Primary Completion: 2019-08-30
• Study Completion: 2019-12-29
• Study First Submitted: 2023-09-26
• Study First Submitted QC: 2023-09-26
• Study First Posted: 2023-10-03
• Status Verified: 2024-01
• Last Update Submitted: 2024-01-03
• Last Update Posted: 2024-01-05

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 137

Inclusion Criteria

• Living in the Philadelphia area
• Attended the study naloxone training.

Exclusion Criteria

• Unable to consent

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Text message nudges	Text message nudges	Participants in this arm receive text message nudges with salient messaging around overdose and naloxone. They also receive naloxone training.
Commitment contract	Commitment contract	Participants in this arm receive sign a commitment contract agreeing to obtain or carry naloxone. They also receive naloxone training.

Primary Outcome Measures

Name	Time	Method
Naloxone carrying	Proportion of successful naloxone check-ins at 14 random time points over a 4 week period post-intervention.	Assessed by photo documentation via text message.

Trial Locations

Locations (2)

University of Pennsylvania Health System; 🇺🇸 Philadelphia, Pennsylvania, United States

University of Pennsylvania; 🇺🇸 Philadelphia, Pennsylvania, United States