Implementation of lower oxygenation targets to improve outcome in ICU patients.
Completed
- Conditions
- High inspiratory oxygen concentrations and high arterial oxygen pressures (PaO2) are independently associated with higher mortality in ICU patients. Although (inter)national guidelines advocate low (physiological) oxygenation targets, ICU-patients in the Netherlands achieve much higher PaO2 values.
- Registration Number
- NL-OMON27410
- Lead Sponsor
- eiden University Medical Center
- Brief Summary
Helmerhorst HJ, Schultz MJ, van der Voort PHJ, Bosman RJ, Juffermans NP, de Jonge E, van Westerloo DJ. Self-reported attitudes versus actual practice of oxygen therapy by ICU nurses and physicians. Annals of Intensive Care 2014, 4:23 http://www.annalsofintensivecare.com/content/4/1/23
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 10000
Inclusion Criteria
All ICU patients admitted during the studyperiod at 3 ICUs, with subgroup analysis in all patients on mechanical ventilation.
Exclusion Criteria
Patients on extracorporeal membrane oxygenation (ECMO).
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Primary End-points will include an analysis of the process of implementation, specifically the mean proportion (per patient) of PaO2 measurements within target range (primary endpoint), mean PaO2 and FiO2, and mean proportion of PaO2 measurements > 16 kPa (hyperoxia). Additional endpoint is the subjective judgement and appreciation of the guideline and the oxygenation targets by physicians and nurses.
- Secondary Outcome Measures
Name Time Method Secondary End-points, Outcome: Hospital mortality, ICU-mortality and days alive and without mechanical ventilation at 28 days after ICU admission. Outcome endpoints will be studied in all ICU patients and in a subgroup of patients that had mechanical ventilation at any time during ICU-stay.